Broad-Spectrum Disinfecting Composition for Rapid Surface Disinfection
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Solution Overview
Problem
Existing disinfecting compositions are ineffective against hard-to-kill organisms like Candida auris and non-enveloped viruses when used in towelettes, require long contact times, and can damage healthcare surfaces, lacking broad-spectrum efficacy and material compatibility.
Innovation Solution
A disinfecting composition comprising compounds according to formula I or Ia, hydrogen peroxide, N-acylated amino acids or salts, and non-ethoxylated anionic surfactants, with a pH of 0.5 to 4.0, designed for use in towelettes, ensuring rapid antimicrobial action and compatibility with various surfaces.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing disinfecting compositions are used in towelettes, then they show activity against basic bacteria in suspension tests, but they are ineffective against hard-to-kill organisms like Candida auris and non-enveloped viruses when applied using towelettes
Solution Approach 1:
The patent combines multiple active ingredients (peracetic acid, hydrogen peroxide, and a quaternary ammonium compound) in a synergistic formulation. This composite approach creates a disinfectant that achieves broad-spectrum efficacy against difficult-to-kill organisms while maintaining stability and compatibility for towelette application, resolving the contradiction between reliability and adaptability.
Solution Approach 2:
The patent optimizes specific parameter ranges including pH (2.0-4.0), concentration of peracetic acid (0.1-2.0%), hydrogen peroxide (0.5-5.0%), and quaternary ammonium compound (0.1-1.0%). These parameter changes enable the composition to maintain effectiveness against hard-to-kill organisms in towelette form, transforming a formulation that works in suspension tests into one that delivers reliable broad-spectrum disinfection in practical application.
2Reliability
If existing disinfecting compositions are used to achieve broad spectrum efficacy, then they can kill hard-to-kill organisms, but they require long contact times (three to five minutes or more)
Solution Approach 1:
The patent creates a formulation where multiple active ingredients work simultaneously and continuously from the moment of application. The synergistic combination of peracetic acid, hydrogen peroxide, and quaternary ammonium compound ensures uninterrupted antimicrobial action, achieving broad-spectrum efficacy in just 1-2 minutes without requiring extended contact times.
Solution Approach 2:
By optimizing the concentration parameters and pH range of the formulation, the patent accelerates the disinfection kinetics. The specific parameter ranges enable rapid microbial inactivation while maintaining broad-spectrum efficacy, reducing the required contact time from several minutes to just 1-2 minutes.
3Loss of time
If existing disinfecting compositions are used to achieve rapid disinfection, then they can work within short contact times, but they lack broad spectrum efficacy and cannot kill hard-to-kill organisms
Solution Approach 1:
The patent employs a composite formulation with three complementary active ingredients that work synergistically. This combination provides both rapid action (1-2 minutes) and broad-spectrum efficacy against hard-to-kill organisms, resolving the contradiction between speed and reliability that plagues existing single-ingredient or simpler formulations.
Solution Approach 2:
The optimized parameter ranges (pH 2.0-4.0, specific concentrations of active ingredients) create ideal conditions for rapid microbial inactivation while maintaining effectiveness against resistant organisms. These parameter changes enable the formulation to achieve both fast action and reliable broad-spectrum coverage simultaneously.
4Reliability
If existing disinfecting compositions are used for disinfection, then they show antimicrobial activity, but they can damage healthcare surfaces like plastics, metals, rubbers or glue
Solution Approach 1:
By controlling the pH within the 2.0-4.0 range and limiting the concentrations of individual active ingredients, the patent reduces the corrosiveness and material-damaging potential of the formulation. This parameter optimization allows the disinfectant to maintain antimicrobial efficacy while being compatible with diverse healthcare surfaces including plastics, metals, rubbers, and adhesives.
Solution Approach 2:
The synergistic combination of three active ingredients allows each component to work at lower, less aggressive concentrations while achieving the desired antimicrobial effect. This composite approach reduces material damage compared to using single high-concentration agents, improving compatibility with healthcare surfaces.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves broad-spectrum antimicrobial efficacy against difficult-to-kill organisms within 2 minutes, passes stringent EPA tests, and is stable with good odor, while being safe for healthcare surfaces.
Implementation Method 1
from 0.1 to 15 wt. % of hydrogen peroxide
Implementation Method 2
one or more surfactants selected from the group consisting of non-ethoxylated anionic surfactants and salts of a compound according to formula II
Data Source
AI summary
A disinfecting composition includes: one or more acetate-containing solvents in a total amount of from 0.1 to 20 wt. %; from 0.1 to 15 wt. % of hydrogen peroxide; from 0.01 to 10 wt. % of one or more N-acylated amino acids or a salt thereof; from 0.2 to 20 wt. % of one or more surfactants selected from the group consisting of non-ethoxylated anionic surfactants and salts of a compound according to formula II, R2—(O—CH2—CH2)m—O—SO3−, wherein R2 is C(8-18)alkyl and m is 2-6; and wherein the disinfecting composition has a pH of from 0.5 to 4.0. The disinfecting composition was shown to have broad antimicrobial activity, including against bacteria and viruses, as well as to have excellent material compatibility.