Brown Algae Polyphenol Coating for Stenosis Prevention
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Solution Overview
Problem
Current treatments for stenosis, such as tracheal and vascular stenosis, often lead to re-stenosis due to excessive tissue growth at the wound site, and existing dilation methods risk airway damage during catheter insertion.
Innovation Solution
A composition incorporating brown algae extract, particularly Ecklonia cava-derived polyphenols, is used to prevent or treat stenosis by coating intubation tubes, which are then administered to patients to inhibit fibrosis and collagen accumulation, reducing the risk of re-stenosis and minimizing tissue damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If resection and anastomosis is performed for tracheal stenosis, then the stenosis is treated, but excessive tissue growth occurs at the wound site causing re-stenosis
Solution Approach 1:
The patent applies preliminary action by coating the intubation tube with brown algae extract before insertion into the patient. This pre-treatment ensures that the active ingredients are already present at the wound site when trauma occurs, preventing excessive tissue growth and re-stenosis before it can happen during the natural healing process
Solution Approach 2:
The brown algae extract acts as an intermediary substance between the intubation tube and the tracheal tissue. It is coated on the tube surface and released at the wound site, mediating the healing process by inhibiting fibrosis and collagen accumulation, thereby preventing re-stenosis without directly removing or compressing tissue
2Reliability
If catheter is inserted for airway dilation, then stenosis is treated, but airway damage may occur during insertion
Solution Approach 1:
The intubation tube is pre-coated with brown algae extract before insertion, so that the protective and anti-inflammatory ingredients are already present on the tube surface. This preliminary treatment reduces tissue trauma and inflammation during the insertion process itself, minimizing airway damage before it can occur
Solution Approach 2:
The brown algae extract coating serves as a protective cushion between the intubation tube and the airway tissue during insertion. This pre-applied protective layer reduces direct mechanical trauma and inflammation caused by the tube, cushioning the airway against damage during the insertion procedure
3Reliability
If stent is inserted for vascular stenosis, then the narrowed vessel is treated, but the blood vessel wall is wounded during insertion
Solution Approach 1:
The stent is pre-coated with brown algae extract before insertion into the blood vessel. This ensures that the active ingredients are already present on the stent surface to protect the vessel wall during insertion and to prevent excessive tissue growth and re-stenosis in the subsequent healing phase
Solution Approach 2:
The brown algae extract coating acts as an intermediary protective layer between the stent and the blood vessel wall. It reduces direct mechanical trauma during insertion and mediates the healing process by inhibiting fibrosis and collagen accumulation, thereby maintaining vascular patency while minimizing vessel wall damage
Data Source
AI summary
The present invention relates to a composition for preventing or treating stenosis, in which the composition includes brown algae extract, and more particularly to a composition for preventing or treating stenosis, in which the composition includes brown algae-derived polyphenol as an active ingredient, thereby providing excellent prevention or treatment effect on stenosis including tracheal stenosis, glottic stenosis, vascular stenosis, and the like.