Black Soldier Fly Larvae Protein Inhibits Intestinal Oxidative Stress
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Solution Overview
Problem
Current treatments for inflammatory intestinal diseases like IBD and chronic enteropathy are inadequate due to low efficacy and side effects, and there is a need for a long-term therapeutic strategy that can reduce inflammation and maintain oxidative balance without adverse effects.
Innovation Solution
A protein composition derived from black soldier fly larvae, which inhibits oxidative damage, macrophage activation, and reactive oxygen species formation, and contains glucosamine to provide anti-inflammatory and protective effects, is used as a food or feed supplement or medicament for prophylaxis and treatment of inflammatory intestinal diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for inflammatory intestinal diseases, then inflammation can be suppressed, but side effects and low efficacy occur
Solution Approach 1:
The patent employs food-grade ingredients and natural compounds instead of potent pharmaceuticals, using safe, short-acting substances that can be administered long-term without accumulating harmful effects. This replaces conventional medications with edible, biodegradable alternatives that minimize side effects while maintaining therapeutic benefit.
Solution Approach 2:
The patent changes the fundamental parameter of treatment from pharmacological intervention to nutritional intervention. By modifying the approach from drug-based to food-based therapy, it achieves anti-inflammatory effects through dietary components that lack the harmful side effects of conventional medications.
2Object-affected harmful factors
If antioxidant enzymes are administered to reduce oxidative stress, then ROS levels decrease, but treatment complexity and cost increase
Solution Approach 1:
The patent enables the body's own antioxidant systems to function by providing substrates and cofactors through diet. Instead of administering complex antioxidant enzymes directly, it supplies nutrients that allow endogenous enzymes like superoxide dismutase and catalase to work effectively, simplifying treatment to basic nutritional support.
Solution Approach 2:
The patent uses food ingredients as intermediaries that indirectly reduce oxidative stress. Rather than directly administering antioxidant enzymes, it provides dietary components that support and enhance the body's natural antioxidant defenses, achieving the same effect through a simpler mediational approach.
3Reliability
If macrophages are activated to fight infection, then immune response increases, but oxidative damage to intestinal tissue worsens
Solution Approach 1:
The patent converts the harmful oxidative byproducts of macrophage activity into beneficial signals by providing antioxidants that modulate macrophage function. This transforms the macrophages' harmful oxidative burst into a controlled, beneficial immune response that eliminates pathogens without causing tissue damage.
Solution Approach 2:
The patent establishes a feedback mechanism where dietary antioxidants monitor and regulate macrophage activity. When oxidative stress becomes excessive, the antioxidant-rich diet provides negative feedback that dampens macrophage activation, preventing tissue damage while maintaining adequate immune function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The black soldier fly larvae protein composition effectively prevents oxidative damage, macrophage activation, and inflammation, offering a multifactorial treatment modality for inflammatory intestinal diseases, addressing multiple contributing factors to disease onset and progression.
Implementation Method 1
the ability of BSF protein derivatives and BSF protein compositions to donate hydrogen atoms and/or electrons to counterpoise unstable molecules
Data Source
AI summary
The invention relates to an insect protein composition for use as a food supplement or a feed supplement, or a medicament, or to an insect protein composition for use in a method for the prophylaxis or treatment of inflammation, in particular inflammatory intestinal diseases, such as IBD and chronic enteropathy. Typically, the insect is black soldier fly larvae. Typically, the protein is water-soluble protein such as a water-soluble protein fraction from insect, and/or enzymatically hydrolysed protein, such as enzymatically hydrolysed insect protein. As part of the invention, the insect protein composition inhibits and/or prevents oxidative damage induced by macrophages and/or inhibits and/or prevents macrophage activation and/or inhibits and/or prevents cell lysis and/or inhibits and/or prevents reactive oxygen species formation by a cell and/or comprises glucosamine. The invention also relates to a food or feed supplement, ingredient or product, comprising the insect protein composition. Furthermore, the invention relates to a non-therapeutic method of prevention against, providing relief from or amelioration of inflammatory intestinal disease, in particular IBD or chronic enteropathy, in a human subject or an animal such as a horse, a pet such as a dog or a cat, preferably a human subject or a dog, the method comprising orally administering to the human subject or the animal the insect protein composition. The invention also relates to a pharmaceutical composition comprising the insect protein composition, and to the pharmaceutical composition for use as a medicament and for use in the treatment or prevention of inflammation.