Bubble Jetting Member for Localized Ablation
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Solution Overview
Problem
Conventional localized ablation and injection methods face challenges such as thermal damage, low resolution, difficulty in accessing targets, inefficient injection, and unsustainable plasma states, particularly when dealing with biological tissues and cells.
Innovation Solution
A bubble jetting member with a conductive core and insulating shell, generating micro/nanoscale bubbles through high-frequency voltage, and a plasma bubble jetting member that maintains plasma within bubbles in a liquid, allowing for precise ablation and injection by ejecting bubbles with adsorbed injection substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If contact process techniques using an electric scalpel are employed for localized ablation, then the cauterization surface can be reduced to several micrometers, but thermal invasion affects surrounding tissue and causes burning away of the target
Solution Approach 1:
The patent replaces the thermal field-based electric scalpel with a mechanical field-based bubble jetting system. High-frequency voltage generates micro/nanobubbles that physically impact the target through cavitation, substituting thermal ablation with mechanical bubble collapse to eliminate thermal invasion while maintaining precise cauterization surfaces
Solution Approach 2:
The patent utilizes phase transition of gas to liquid through bubble collapse. Micro/nanobubbles generated by high-frequency voltage collapse upon contact with the target, converting gas phase to liquid phase and generating localized mechanical impact for ablation without thermal effects
2Productivity
If continuous high-frequency process is applied, then ablation can be performed continuously, but adsorption of bubbles and proteins onto the probe degrades the observation environment
Solution Approach 1:
The patent extracts the bubble generation function from a traditional solid probe into a separate bubble jetting member that ejects bubbles into the liquid medium. This separation prevents bubble and protein adsorption on the electrode, maintaining a clean observation environment while enabling continuous processing through sustained bubble generation and ejection
Solution Approach 2:
The patent introduces bubbles as an intermediary between the electrode and the target. Instead of direct contact between the probe and target, bubbles serve as the active medium that carries out the ablation function, preventing direct adsorption of proteins and bubbles onto the electrode surface
3Object-affected harmful factors
If non-contact process techniques employing lasers are used, then bubbles can be minimized, but difficulty in accessing the process target and localized bombardment with high-density energy occurs
Solution Approach 1:
The patent employs pneumatic principles by generating and ejecting micro/nanobubbles into the liquid medium to reach the target. This bubble-based approach allows access to targets that are difficult to reach with traditional probes, while the bubbles themselves minimize harmful thermal effects compared to laser methods
4Adaptability or versatility
If electroporation or sonoporation techniques are employed for injection, then substances can be introduced into cells, but the cell membrane may be damaged or the process is limited to specific cell types
Solution Approach 1:
The patent changes the physical parameters of the injection process by using micro/nanobubbles with controlled size, pressure, and collapse characteristics. This allows adjustment of the injection intensity to match different cell types and membrane strengths, enhancing versatility while preserving cell membrane integrity through optimized bubble parameters
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables minimal damage to biological tissues, high-resolution ablation and injection, efficient delivery of substances, and sustained plasma states, addressing the limitations of existing methods.
Implementation Method 1
generating micro/nanoscale bubbles through high-frequency voltage
Implementation Method 2
maintains plasma within bubbles in a liquid
Implementation Method 3
ejecting bubbles with adsorbed injection substances
Data Source
AI summary
Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma.Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage. By further providing an outside shell part at the outer periphery of the shell part, bubbles onto which a solution containing an injection substance has been adsorbed can be ejected, and the injection substance can be introduced during localized ablation of the process target. Additionally, by including a pair of electrodes formed from a conducting material, for generating a plasma in an inert gas, a liquid flow passage through which a liquid flows, and a microscopic flow passage for flow of an inert gas, an inert gas containing a plasma, and bubbles of inert gas containing a plasma, the liquid flow passage and the microscopic flow passage connecting at the downstream side from a section in which plasma is generated in the microscopic flow passage, bubbles containing a plasma can be generated, and can maintain a plasma state even in liquid, whereby therapy of biological tissue can be effected with the plasma.