Buccal Micro-Effervescent Tablet Saliva Activation
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Solution Overview
Problem
Conventional effervescent tablets require dissolution in water, which can be inconvenient without access to drinking equipment or water, leading to user discomfort and potential safety risks due to carbon dioxide generation.
Innovation Solution
Development of a buccal micro-effervescent tablet that generates micro-effervescence upon contact with saliva, comprising a nutrient, sugar alcohol, acid source, alkali source, magnesium stearate, essence, and sweetening agent, allowing for direct administration in the mouth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional effervescent tablets are used, then rapid disintegration and high bioavailability are achieved, but the requirement for water dissolution creates inconvenience and safety risks
Solution Approach 1:
The patent changes the effervescence parameter from macro-scale (requiring water dissolution) to micro-scale (direct buccal dissolution). This is achieved by controlling the particle size and composition of the effervescent agents, allowing the tablet to produce mild effervescence directly in the mouth without requiring water, thereby improving convenience and eliminating safety risks associated with water-less administration
Solution Approach 2:
The patent introduces saliva as an intermediary medium to replace water for dissolution. By formulating the tablet to react with saliva components, the effervescent reaction occurs naturally in the mouth, eliminating the need for external water sources and making the preparation suitable for use in situations where water is unavailable
2Ease of operation
If effervescent tablets are designed for water dissolution, then fast action and high bioavailability are achieved, but user convenience deteriorates without drinking equipment
Solution Approach 1:
The patent segments the effervescent reaction into micro-bubbles rather than a single macro effervescence event. This segmentation allows the reaction to occur progressively as the tablet dissolves in saliva, maintaining the fast action benefit while enabling the tablet to be taken without water, thus improving portability and ease of use in outdoor or travel situations
3Productivity
If large amounts of acid and alkali sources are used for effervescence, then rapid disintegration is achieved, but carbon dioxide generation creates safety concerns
Solution Approach 1:
The patent applies partial action by using controlled, moderate amounts of acid and alkali sources that produce sufficient effervescence for rapid disintegration but not excessive carbon dioxide generation. The formulation balances the effervescent agents to achieve the necessary disintegration speed while keeping gas production at safe, manageable levels that do not pose safety risks
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The buccal micro-effervescent tablet provides a convenient and safe method for nutrient delivery, avoiding the need for water and minimizing the risk of carbon dioxide-related safety issues, while maintaining good taste and bioavailability.
Implementation Method 1
the effervescent tablet is placed into water, and the organic acid reacts with the basic (bi)carbonate instantly to generate and release a large amount of carbon dioxide gas
Implementation Method 2
can cause micro effervescence under the action of saliva in mouth
Data Source
AI summary
Provided is a buccal micro-effervescent tablet and preparation method thereof. The buccal micro-effervescent tablet includes a nutrient, a sugar alcohol, an acid source, an alkali source, magnesium stearate, an essence and a sweetening agent, wherein the sugar alcohol is lactose, maltitol, sorbitol, isomaltitol, mannitol, erythritol or any combination thereof and the sweetening agent is sucralose, aspartame, stevioside, fructose, granulated sugar, mogroside or any combination thereof. The micro-effervescent tablet is configured to cause a micro effervescence reaction under the action of saliva in mouth.