Buccal Mucoadhesive Patch for Protein Release
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Solution Overview
Problem
The oral administration of proteins is challenging due to their sensitivity to gastrointestinal enzymes, and there is a need for a mucoadhesive system with optimized permeation capacity to reduce therapeutic doses and improve absorption control.
Innovation Solution
A mucoadhesive patch comprising multiple bilayers of chitosan and hyaluronic acid, designed for buccal or sublingual application, which adheres to the mucosa, allowing controlled release of proteins and peptides, and is self-supporting, dissolving in saliva to facilitate enzyme degradation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If proteins are administered orally, then the administration route is simple and widely used, but the proteins are degraded by gastrointestinal enzymes and absorption is poor
Solution Approach 1:
The invention extracts the protein delivery system from the gastrointestinal tract environment and relocates it to the buccal cavity, where enzymes are absent. The mucoadhesive patch delivers proteins directly through the buccal mucosa, bypassing the harmful gastrointestinal enzymatic environment while maintaining simple administration.
Solution Approach 2:
The mucoadhesive patch acts as an intermediary delivery system that enables protein transport across the buccal mucosa. It mediates between the protein cargo and the mucosal tissue, facilitating controlled release and absorption while protecting the protein from degradation.
2Reliability
If a mucoadhesive system is used for protein delivery, then absorption control is improved, but the permeation capacity needs optimization to reduce therapeutic dose
Solution Approach 1:
The invention optimizes the mucoadhesive system by adjusting key parameters: using specific polysaccharide combinations (chitosan and hyaluronic acid) with controlled molecular weights, optimizing bilayer structure and thickness, and tuning the mucoadhesive strength to achieve ideal balance between retention time and permeation capacity, thereby reducing the required therapeutic dose.
Solution Approach 2:
The patch employs a composite structure combining chitosan and hyaluronic acid bilayers. This composite material system provides enhanced mucoadhesion, controlled permeation, and optimized drug release profile, allowing for reduced therapeutic doses while maintaining effective absorption control.
3Reliability
If multiple bilayers are used in the patch, then controlled release and permeation are improved, but the device complexity increases
Solution Approach 1:
The patch is segmented into multiple thin bilayer units (chitosan-hyaluronic acid repeats), where each layer contributes specific functions. This segmentation allows controlled release through the layered structure while maintaining a relatively simple overall design that can be fabricated using straightforward layer-by-layer assembly techniques.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch provides controlled and efficient absorption of proteins, maintaining bioactivity and avoiding inflammation, with prolonged retention and penetration into the mucosa, effectively reducing the therapeutic dose required.
Implementation Method 1
forming a CHI/anionic polysaccharide multilayer membrane by a method of layer by layer deposition on a substrate
Implementation Method 2
The patch adheres to the buccal or sublingual mucosa
Implementation Method 3
said protein or said polypeptide being incorporated in said patch and/or adsorbed on the surface of said patch
Implementation Method 4
The patch is self-supporting and dissolves in the saliva owing to the presence of enzymes capable of degrading the two polysaccharides
Data Source
AI summary
The present invention relates to a mucoadhesive patch for buccal or sublingual release of a protein or polypeptide, said patch comprising at least 100 bilayers each composed of a layer of chitosan (CHI) and a layer of an anionic polysaccharide. The invention also relates to a method for producing such a patch.