Buffalo Milk Whey Composition for Intestinal Barrier Integrity
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Solution Overview
Problem
Current treatments for chronic inflammatory bowel disorders such as ulcerative colitis, ulcerative rectal colitis, Crohn's disease, and irritable bowel syndrome (IBS) are associated with side-effects, dependence, and resistance, necessitating an effective, side-effect-free solution to regulate intestinal permeability and restore the intestinal barrier.
Innovation Solution
A nutraceutical composition comprising lyophilized buffalo milk whey from the Italian Mediterranean breed, formulated as gastro-resistant capsules, is administered to reduce intestinal permeability and strengthen the intestinal barrier by reducing spaces between cells and consolidating tight junctions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional pharmacological therapies are used to treat chronic inflammatory bowel disorders, then symptom relief is achieved, but intestinal barrier integrity is not maintained and side effects occur
Solution Approach 1:
The patent changes the chemical composition parameters by using buffalo milk whey with specific protein content (1.10g/100g) and bioactive peptides, creating a nutraceutical formulation that restores intestinal barrier integrity without the harmful side effects of conventional pharmacological therapies
Solution Approach 2:
The patent introduces buffalo milk whey as an intermediary substance that mediates between the intestinal mucosa and toxic agents, consolidating tight junctions and reducing permeability without directly attacking the pathology like traditional drugs
2Reliability
If conventional treatments are administered, then acute symptoms are suppressed, but intestinal permeability remains impaired
Solution Approach 1:
The patent establishes continuous useful action by formulating a nutraceutical composition that maintains intestinal barrier integrity over time, with buffalo milk whey peptides continuously consolidating tight junctions and preventing permeability impairment throughout the treatment period
Solution Approach 2:
The patent applies preliminary action by using buffalo milk whey that pre-consolidates tight junctions before toxic agents can penetrate, creating a protective barrier function that prevents permeability impairment rather than merely treating it after occurrence
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces intestinal permeability, alleviating symptoms of inflammatory bowel diseases by maintaining the intestinal barrier function, thus improving the quality of life for patients with chronic intestinal disorders.
Implementation Method 1
reduces intestinal permeability by consolidating tight junctions between intestinal mucosa cells and reducing the absorption of toxic agents
Data Source
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AI summary
The present invention is aimed at a nutraceutical composition comprising or consisting of buffalo milk whey preferably buffalo of the Italian Mediterranean breed, and its use for the reduction of intestinal permeability.