Automated Buffer Preparation Control System
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Solution Overview
Problem
Existing methods and tools are inadequate for preparing complex buffer solutions, particularly those involving additional components and salts, and do not support the calculation and control of parameters such as buffer concentration, salt concentration, and flow rates in chromatography systems.
Innovation Solution
A computer-implemented method and tool for calculating and automating the preparation of liquid mixtures, including buffers with multiple buffering species and additives, by determining relative component proportions and pump settings based on desired pH, ionic strength, and buffer capacity, using algorithms and feedback control to ensure precise composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional buffer mixing devices are used, then simple buffer solutions can be prepared, but complex buffer solutions with multiple components and salts cannot be properly controlled
Solution Approach 1:
The control system segments the buffer preparation process into multiple independent control loops, each managing a specific parameter (pH, ionic strength, concentration, flow rates). This allows complex buffers with multiple components to be prepared by controlling each aspect separately through dedicated sensors and actuators, thereby achieving versatility without overwhelming complexity.
Solution Approach 2:
The system dynamically adjusts control parameters based on real-time feedback from sensors. The control system can adapt flow rates, pump speeds, and mixing conditions on-the-fly to achieve desired buffer composition, enabling preparation of complex buffers with precise control over multiple simultaneous parameters.
2Measurement precision
If feedback control is applied to maintain buffer accuracy, then pH control is improved, but control of multiple parameters simultaneously becomes difficult
Solution Approach 1:
The feedback control system is segmented into multiple independent control loops, each dedicated to a specific parameter (pH, ionic strength, concentration). Each loop uses its own sensor and actuator pair, allowing precise control of individual parameters without interference from others, thus maintaining accuracy while managing complexity.
Solution Approach 2:
The system implements feedback control by continuously monitoring parameters with sensors and adjusting process variables accordingly. Real-time feedback from pH sensors, conductivity sensors, and flow meters enables the control system to maintain precise composition by making dynamic corrections to pump rates and mixing conditions.
3Adaptability or versatility
If multiple components and salts are added to buffers, then buffer functionality is enhanced, but calculation and control of relative concentrations becomes complex
Solution Approach 1:
The control system performs self-calibration and automatic calculation of required component concentrations based on target buffer specifications. It automatically determines the precise amounts of each component and salt needed, eliminating manual calculation errors and simplifying the manufacturing process while maintaining enhanced buffer functionality.
Solution Approach 2:
The system manages complexity by dynamically adjusting and optimizing parameter relationships. It calculates and controls the relative concentrations of multiple components and salts by changing process parameters (flow rates, mixing ratios) in a coordinated manner, making the preparation of functionally enhanced buffers straightforward despite the increased number of components.
4Productivity
If automated preparation is implemented, then preparation time is reduced, but system complexity increases
Solution Approach 1:
The automated system performs self-programming and self-execution of buffer preparation protocols. It automatically retrieves component information, calculates required amounts, controls pump operations, and monitors completion without human intervention. This self-service automation reduces preparation time while managing complexity through standardized, pre-configured control logic.
Solution Approach 2:
The system replaces manual mechanical operations with automated electronic control. Pump controllers, valve actuators, and sensors work together to automatically measure and mix components, eliminating manual pouring and measurement. This substitution increases productivity by reducing preparation time while managing complexity through software-based control rather than physical complexity.
Data Source
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AI summary
The present invention relates to a computer-implemented method for controlling preparation of a liquid mixture comprising an acid and its conjugate base or a base and its conjugate acid. The method comprises obtaining (S11) a composition for the liquid mixture to be prepared and determining (S12) a plurality of settings for controlling a preparation of the liquid mixture in one or more automated processes. The plurality of settings are provided (S13) to one or more control systems of the one or more automated processes. The present invention also relates to a buffer tool configured to perform the computer-implemented method, a buffer management system comprising the buffer tool, and a computer readable storage medium (25), having stored thereon a computer program which, when executed in a buffer tool, causes execution of the computer-implemented method.