Buffered Basic Cleaning Solution for Biochemical Analyzer
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Solution Overview
Problem
Conventional cleaning solutions for automatic biochemical analyzers are often incompatible, corrosive, or environmentally harmful, leading to inaccurate test results and potential clinical misdiagnosis, as they are not specifically designed for these analyzers and may require sequential use of acidic and basic solutions, which increases costs and risks.
Innovation Solution
A non-corrosive, pollution-free cleaning solution comprising anionic and non-ionic surfactants, alkali metal hydroxide, alkali metal citrate, and a buffering agent to stabilize the pH above 13.0, which effectively removes organic and inorganic materials from the reaction cup, reducing residual rates and cross-contamination while being environmentally friendly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cleaning solutions are used, then cleaning effect is achieved, but compatibility and corrosiveness worsen
Solution Approach 1:
The patent changes the chemical parameters of the cleaning solution by using a buffered basic solution with pH 8.0-10.0 instead of strong acids or bases, and by controlling the concentration of surfactants (0.1-10% w/v) and chelating agents (0.01-5% w/v), achieving effective cleaning while reducing corrosiveness to analyzer components
Solution Approach 2:
The cleaning solution combines multiple components including buffered basic solution, surfactants (anionic, nonionic, cationic, or amphoteric), and chelating agents in specific concentrations to create a composite formulation that provides both cleaning effectiveness and compatibility with analyzer components
2Reliability
If sequential acidic and basic solutions are used, then cleaning thoroughness is improved, but costs and complexity increase
Solution Approach 1:
The patent merges the functions of multiple cleaning solutions (acidic and basic) into a single buffered basic cleaning solution that can effectively remove both organic and inorganic deposits, eliminating the need for sequential cleaning steps and reducing process complexity
Solution Approach 2:
The cleaning solution is designed with multi-functionality to perform various cleaning tasks including removal of organic residues, inorganic deposits, and protein films through its combination of surfactants and chelating agents in a buffered basic formulation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides enhanced cleaning effects, reduces the need for sequential washing, lowers clinical testing costs, and ensures accurate and reliable test results by being non-corrosive to the analyzer's components and environmentally friendly.
Implementation Method 1
The cleaning solution contains anionic and non-ionic surfactants which reduce surface tension and emulsify organic and inorganic materials, enabling effective removal from the reaction cup surface
Implementation Method 2
The cleaning solution comprises alkali metal hydroxide and a buffering agent to stabilize the pH value above 13.0, creating a strongly basic environment that dissolves acidic residues and denatures organic materials for easier removal
Implementation Method 3
The cleaning solution includes alkali metal citrate which functions as a chelating agent, forming stable complexes with metal ions through coordinate covalent bonds, thereby removing inorganic deposits from the reaction cup surface
Data Source
AI summary
A method of cleaning an automatic biochemical analyzer, wherein the cleaning solution includes: at least one anionic surfactant, at least one nonionic surfactant, an alkali metal hydroxide, an alkali metal citrate, and a buffering agent stabilizing the pH value above 13.0. In some embodiments, the cleaning solution provides low residual rate of proteins, low residual rate of lipids, desirable within-batch repeatability in clinical testing, low level of cross-contamination, and low level of reactant deposit after cleaning, without affecting test results of the biochemical analyzer. In some embodiments, the cleaning solution has no corrosive effects on the liquid path and reaction cup of the analyzer. The ingredients of the cleaning solution may also be biodegradable.