Buffered Caffeine Aerosol Formulation for Solubility Consistency
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Solution Overview
Problem
Existing aerosol delivery systems face challenges in formulating aerosolisable materials that ensure consistent quality, solubility, and specific aerosol profiles, particularly for caffeine-based formulations.
Innovation Solution
An aerosolisable formulation comprising caffeine, a solvent selected from water, propylene glycol, or glycerol, and a buffer comprising benzoic acid and a benzoate, which improves caffeine solubility and formulation consistency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If caffeine is formulated in traditional aerosol systems, then the desired aerosol profile can be achieved, but solubility and quality consistency deteriorate
Solution Approach 1:
The patent introduces a buffer system comprising benzoic acid and a benzoate as an intermediary substance that mediates between caffeine and the solvent. This buffer system improves caffeine solubility and stabilizes the formulation, directly resolving the contradiction between achieving desired aerosol profile and maintaining quality consistency.
Solution Approach 2:
The patent modifies the chemical parameters of the formulation by introducing specific buffer components (benzoic acid and benzoate) and optimizing their concentrations. This changes the pH and ionic environment, thereby improving caffeine solubility and formulation stability without compromising the aerosol profile.
2Quantity of substance
If buffer comprising benzoic acid and a benzoate is added to improve solubility, then caffeine solubility improves, but formulation complexity increases
Solution Approach 1:
The buffer system serves multiple functions simultaneously: it acts as a pH regulator, a solubility enhancer, and a stability agent. By combining these functions into a single buffer component system, the patent avoids adding multiple separate additives, thereby limiting the increase in formulation complexity while achieving improved caffeine solubility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The inclusion of benzoic acid and a benzoate buffer enhances caffeine solubility and formulation quality, providing a consistent and effective aerosol delivery system.
Implementation Method 1
a buffer comprising benzoic acid and a benzoate
Implementation Method 2
a solvent selected from water, propylene glycol, glycerol and mixtures thereof
Implementation Method 3
an aerosol generator which is capable of converting an aerosolisable material into an aerosol. In some instances, the aerosol generated is a condensation aerosol whereby an aerosolisable material is heated to form a vapor which is then allowed to condense into an aerosol
Implementation Method 4
heated to form a vapor which is then allowed to condense into an aerosol
Implementation Method 5
Such atomization may be brought about mechanically, e.g. by subjecting the aerosolisable material to vibrations so as to form small particles of material that are entrained in airflow
Data Source
AI summary
There is provided an aerosolisable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerol and mixtures thereof; and (ill) a buffer comprising benzoic acid and a benzoate.