Buffered Salt Solution for Microvolume Blood GA Stability

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Solution Overview

Problem

During transportation or storage of microvolume blood samples, the reaction between albumin and glucose leads to changes in the glycated albumin (GA) value, affecting the accuracy of GA measurements.

Innovation Solution

A dilution solution containing a buffering agent and a salt is used to dilute the blood sample at a ratio greater than 8, inhibiting the glycation reaction and maintaining GA value accuracy during transport or storage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If microvolume blood is transported or stored without dilution, then the blood sample volume is preserved, but the GA value changes due to glycation reaction between albumin and glucose

Engineering Contradiction:

Improveblood sample volumeVSAvoidGA value accuracy

Core Design Contradiction:

Quantity of substanceVSMeasurement precision

Solution Approach 1:

The patent changes the concentration parameter by diluting the blood sample with a dilution solution. This reduces the concentration of glucose and albumin, thereby suppressing the glycation reaction rate while preserving the blood sample volume for transportation and storage

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces a dilution solution as an intermediary substance between the blood components (albumin and glucose). This intermediary medium reduces the direct interaction frequency between albumin and glucose, preventing unwanted chemical reactions during storage

Inventive Principle:

Principle #24Intermediary (Mediator)

2Stability of the object's composition

If the blood sample is diluted to prevent glycation, then the GA value stability is improved, but the blood sample concentration decreases

Engineering Contradiction:

ImproveGA value stabilityVSAvoidblood component concentration

Core Design Contradiction:

Stability of the object's compositionVSQuantity of substance

Solution Approach 1:

The patent optimizes the dilution ratio parameter to achieve a balance where the GA value remains stable (within acceptable measurement ranges) while maintaining sufficient blood component concentration for accurate analysis. The dilution ratio is specifically controlled to prevent excessive concentration loss

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution effectively stabilizes the GA value by reducing the frequency of albumin-glucose interaction, allowing accurate GA measurement even after several days, thus enabling efficient and precise blood glucose control.

Implementation Method 1

The solution may be configured to dilute the blood at a dilution ratio of greater than 8

Methodology Applied

Scientific EffectDilution:

Data Source

PatentEP4628890A1Solution and method for transporting or holding blood in very small amount

Publication Date: 2025.10.08 PROVIGATE KK

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AI summary

According to an embodiment of the present disclosure, a solution for transporting or storing a blood sample is provided. The blood sample may be a microvolume blood sample. In some embodiments, the solution may contain a buffering agent and a salt as active ingredients. The solution may be configured to dilute the blood at a dilution ratio of 10 or greater.