Buffered Vigabatrin Oral Solution for Stability and Palatability
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Solution Overview
Problem
Existing liquid pharmaceutical compositions for oral delivery face challenges in solubility, stability, taste masking, and patient compliance, particularly for pediatric and geriatric patients, with many drugs being poorly soluble and having poor bioavailability.
Innovation Solution
A pharmaceutical composition comprising an active pharmaceutical ingredient, a buffering agent, and water, formulated to maintain a pH between 5 and 8, with optional excipients for taste masking and stability, suitable for oral delivery in the form of aqueous solutions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If liquid pharmaceutical compositions are formulated for oral delivery, then patient compliance is improved, but stability and solubility are compromised
Solution Approach 1:
The patent applies parameter changes by adjusting the pH of the liquid composition to specific ranges (pH 3-7, preferably pH 4-6) to optimize both stability and solubility. This involves modifying chemical parameters (pH, ionic strength) and physical parameters (temperature, concentration) to achieve the desired balance between patient compliance and drug stability in liquid formulations
2Ease of operation
If liquid formulations are used instead of solid tablets, then patient compliance is improved, but manufacturing complexity increases
Solution Approach 1:
The patent extracts and eliminates unnecessary excipients from the formulation by using a simplified liquid composition that requires fewer additives compared to conventional liquid formulations. This reduction in formulation complexity while maintaining patient compliance benefits is achieved by focusing on essential components only
3Stability of the object's composition
If conventional liquid formulations are used, then solubility is improved, but taste and palatability deteriorate
Solution Approach 1:
The patent uses parameter changes by adjusting pH to optimize both solubility and taste. By controlling the pH within specific ranges, the formulation achieves adequate drug solubility while minimizing bitter tastes and improving overall palatability, making the liquid formulation acceptable to pediatric and geriatric patients
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides improved stability, palatability, and patient compliance, with enhanced bioavailability and dissolution profiles, making it suitable for pediatric and geriatric patients.
Implementation Method 1
a buffering agent, and water, wherein the pH of the composition is between about pH 5 and about pH 8
Data Source
AI summary
This disclosure relates to pharmaceutical compositions in the form of a solution for oral delivery. Particularly, the pharmaceutical compositions comprise an active pharmaceutical ingredient, a buffering agent, and water. In some embodiments, the pH of the composition is from about pH 5 to about pH 8. In some embodiments, the active pharmaceutical ingredient is selected from ramipril, solifenacin, vigabatrin, losartan potassium, warfarin, and melatonin.