Bullfrog Collagen Crosslinked Matrix for Wound Healing
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Solution Overview
Problem
Current wound healing technologies face challenges with collagen-based wound dressings due to rapid degradation, poor adhesion, and slow cell proliferation, particularly from mammalian sources which raise cultural and health concerns, and marine collagen suffers from thermal instability.
Innovation Solution
Development of a crosslinked polymer matrix using non-mammalian type I collagen, such as from bullfrog skin, with a crosslinking agent like 1,4-butanediol diglycidyl ether, enhancing structural and functional properties, and incorporating antibacterial compounds like silver nanoparticles for improved wound healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If marine collagen is used for wound dressings, then cultural and health concerns are avoided, but thermal stability is poor leading to rapid denaturation
Solution Approach 1:
The patent creates a composite material by crosslinking marine collagen with 1,4-butanediol diglycidyl ether (BDE). This crosslinked composite structure combines the biocompatibility of marine collagen with the enhanced thermal stability provided by the crosslinking network, resolving the contradiction between safety and thermal stability.
Solution Approach 2:
The patent changes the chemical structure parameter of marine collagen through crosslinking modification. By introducing crosslinking agents and forming a crosslinked polymer matrix, the thermal denaturation temperature is increased from approximately 37°C to above 60°C, thereby improving thermal stability while maintaining biocompatibility.
2Stability of the object's composition
If mammalian collagen is used for wound dressings, then thermal stability is good, but cultural and religious issues arise along with disease transmission concerns
Solution Approach 1:
The patent uses marine collagen from alternative sources (fish scales, skin, bones) that are culturally acceptable and free from disease transmission risks. The crosslinked structure extends the functional lifetime of the material, making it suitable for wound dressings while avoiding the harmful associations of mammalian sources.
3Reliability
If conventional collagen is used for wound dressings, then biocompatibility is good, but degradation rate is rapid reducing effectiveness
Solution Approach 1:
The patent creates a crosslinked composite material where the crosslinking network slows down enzymatic degradation while maintaining biocompatibility. The crosslinked polymer matrix provides structural integrity over extended periods, resolving the contradiction between rapid degradation and biocompatibility.
Solution Approach 2:
The patent changes the chemical structure by introducing crosslinks between collagen molecules. This structural modification reduces the accessibility of collagen to degrading enzymes while preserving cell interaction capabilities, thereby extending the functional duration of the wound dressing.
4Quantity of substance
If marine collagen is extracted using conventional methods, then collagen is obtained, but the process is complex and time-consuming
Solution Approach 1:
The patent optimizes extraction parameters including using acidic solutions (acetic acid, HCl) at controlled pH levels (2.0-3.0), temperatures (4-25°C), and time periods (12-48 hours). These parameter optimizations simplify the extraction process while improving collagen yield and quality, making it less complex than conventional methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified marine collagen-based wound dressings exhibit enhanced re-epithelialization, improved wound closure, and increased cell migration with moderated cell adhesion, while being more cost-effective and reducing health risks associated with mammalian-derived materials.
Implementation Method 1
a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent
Implementation Method 2
a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking
Implementation Method 3
incorporating antibacterial compounds like silver nanoparticles for improved wound healing
Data Source
AI summary
Disclosed herein is a polymeric material that includes a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent and/or a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking, wherein the non-mammalian collagen is type I collagen. Also disclosed herein is a wound dressing that incorporates said material and methods of treatment of a wound with said polymeric material or said wound dressing.