Burdock Nano-Micro Emulsion via Phospholipid Mediator
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Solution Overview
Problem
Existing burdock composite essence in the form of nanomicell solution suffers from poor absorption due to oil phase insolubility in water, limiting the health benefits of soluble ingredients like Shikonin and Angelica after oral administration.
Innovation Solution
A process involving mixing heated phospholipid with vegetable oil extract, adding glycerol, and high-speed homogenization followed by high-pressure homogenization and filtration to create a nano-micro emulsion, resulting in a burdock concentrate that is easily absorbed by the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If nanomicell solution formulation is used with oil phase, then effective ingredients like Shikonin and Angelica can be incorporated, but the oil phase is not soluble in water causing poor absorption and health effect
Solution Approach 1:
The patent introduces phospholipids as intermediary substances that act as emulsifiers between the oil phase containing effective ingredients and the aqueous phase. The phospholipids form micellar structures that solubilize the oil-soluble ingredients (Shikonin and Angelica) in water, enabling both incorporation and absorption. This mediator resolves the contradiction by allowing the oil phase to be dispersed in water without precipitation.
Solution Approach 2:
The patent changes the physical and chemical parameters of the formulation by controlling the HLB value (Hydrophile-Lipophile Balance) of the phospholipid emulsifier and adjusting the temperature during preparation. By optimizing these parameters, the formulation achieves stable nano-micro emulsion that maintains solubility of oil-phase ingredients while ensuring water compatibility and absorption.
2Reliability
If high-speed homogenization and high-pressure homogenization are applied, then uniform nano-micro emulsion is formed improving absorption, but the process complexity increases
Solution Approach 1:
The patent applies preliminary action by performing high-speed homogenization before high-pressure homogenization. The initial high-speed stirring pre-distributes the phospholipids and creates preliminary emulsion droplets, which then undergo further refinement in the high-pressure homogenizer. This sequential approach achieves uniform nano-micro emulsion while reducing the burden on individual homogenization steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process enhances the absorption of burdock essence, improving health benefits by ensuring effective delivery of bioactive compounds post-administration.
Implementation Method 1
dissolved and heated phospholipid is added to a vegetable oil extract and then stirred; after stirring, the above mixture is pour into a heated glycerol and then further stirred
Implementation Method 2
the aforementioned mixed solution is stirred at high speed; the emulsion-homogenized solution is subject to high-pressure homogenization
Implementation Method 3
dissolved and heated phospholipid is added to a vegetable oil extract; the vegetable oil extract is ready for use after being heated in water bath at 80° C.
Implementation Method 4
a filtration membrane is used to filter the homogenized solution to get a purple transparent burdock concentrate
Data Source
AI summary
A process of preparing a burdock composite micron essence at least includes the following. Dissolved and heated phospholipid is added to a vegetable oil extract and then stirred. After stirring, the above mixture is pour into a heated glycerol and then further stirred and a burdock extract aqueous solution is added. The aforementioned mixed solution is stirred at high speed, the emulsion-homogenized solution is subject to high-pressure homogenization, and a filtration membrane is used to filter the homogenized solution obtained to get a purple transparent burdock concentrate. The burdock concentrate is used to prepare the formulation of nano-micro emulsion which is easily absorbed by human body and thus grants improved health benefits.