1,4-Butanediol Purification via Ion Exchange Resins

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current processes for producing 1,4-butanediol from renewable sources result in impurities that reduce the purity and stability of the final product, affecting the quality of biodegradable polyesters, particularly due to high contents of 2-pyrrolidone and 2-(4′-hydroxybutoxy)-tetrahydrofuran, which impact hydrolysis resistance and productivity.

Innovation Solution

A process involving the use of cationic and anionic exchange resins at specific pH ranges followed by distillation to purify 1,4-butanediol, reducing 2-pyrrolidone content to less than 6 ppm and 2-(4′-hydroxybutoxy)-tetrahydrofuran to less than 800 ppm, enhancing the purity and stability of the diol for polyester synthesis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If 1,4-butanediol is produced from renewable sources via fermentation, then the use of non-renewable resources decreases and CO2 emissions decrease, but the product contains high levels of impurities that reduce polyester quality

Engineering Contradiction:
Improveuse of renewable sourcesVSAvoidpurity of 1,4-butanediol
Core Design Contradiction:
Adaptability or versatilityVSManufacturing precision

Solution Approach 1:

The purification process is divided into multiple sequential stages: first distillation to remove volatile impurities, followed by ion exchange to remove nitrogen-containing compounds, then a second distillation to remove 2-pyrrolidone and 2-(4'-hydroxybutoxy)-tetrahydrofuran. This segmented approach achieves high purity while maintaining renewable source production

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The process controls and adjusts various parameters including distillation temperatures, ion exchange resin types and quantities, pH levels during ion exchange, and residence times to optimize the removal of specific impurities while preserving the 1,4-butanediol product

Inventive Principle:
Principle #35Parameter changes

2Ease of manufacture

If high contents of impurities such as 2-pyrrolidone and 2-(4'-hydroxybutoxy)-tetrahydrofuran are present in 1,4-butanediol, then the fermentation process is simpler, but the resulting polyesters have reduced hydrolysis resistance and productivity

Engineering Contradiction:
Improvesimplicity of fermentation processVSAvoidhydrolysis resistance of polyester
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The process specifically extracts and removes harmful impurities: 2-pyrrolidone is removed through controlled distillation at specific temperature ranges, while 2-(4'-hydroxybutoxy)-tetrahydrofuran is removed through ion exchange resins and subsequent distillation, thereby improving polyester hydrolysis resistance without complicating the fermentation process

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

Ion exchange resins are introduced as intermediary materials to selectively bind and remove nitrogen-containing impurities and cyclic by-products from the 1,4-butanediol stream, protecting the final polyester product from hydrolysis degradation

Inventive Principle:
Principle #24Intermediary (Mediator)

3Device complexity

If conventional distillation is used to purify 1,4-butanediol, then the purification process is simpler, but it cannot effectively remove 2-pyrrolidone and 2-(4'-hydroxybutoxy)-tetrahydrofuran impurities

Engineering Contradiction:
Improvesimplicity of purification processVSAvoidremoval of specific impurities
Core Design Contradiction:
Device complexityVSManufacturing precision

Solution Approach 1:

The process merges multiple purification techniques: conventional distillation is combined with ion exchange treatment, followed by additional distillation steps. This combination achieves effective removal of 2-pyrrolidone and 2-(4'-hydroxybutoxy)-tetrahydrofuran while maintaining overall process manageability

Inventive Principle:
Principle #5Merging (Combining)

4Quantity of substance

If impurities are present in 1,4-butanediol from renewable sources, then the production cost is lower, but the polyester synthesis requires substantial changes in process conditions to adjust final viscosity

Engineering Contradiction:
Improvecost effectiveness of productionVSAvoidflexibility in polyester synthesis conditions
Core Design Contradiction:
Quantity of substanceVSAdaptability or versatility

Solution Approach 1:

The purification process is performed preliminarily before polyester synthesis to remove impurities that would otherwise require adjustments in polymerization conditions. By pre-removing 2-pyrrolidone and 2-(4'-hydroxybutoxy)-tetrahydrofuran, the polyester synthesis can proceed under standard conditions without requiring substantial changes to achieve desired viscosity

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The process achieves a 1,4-butanediol composition with a concentration of 99.0% by weight and low impurity levels, maintaining stable APHA color values over time, eliminating the need for post-treatment purification and enabling the production of biodegradable polyesters with improved mechanical properties.

Implementation Method 1

A process involving the use of cationic and anionic exchange resins at specific pH ranges followed by distillation to purify 1,4-butanediol

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

followed by distillation to purify 1,4-butanediol, reducing 2-pyrrolidone content to less than 6 ppm and 2-(4'-hydroxybutoxy)-tetrahydrofuran to less than 800 ppm

Methodology Applied
Scientific EffectDistillation: Distillation

Implementation Method 3

1,4-butanediol may be obtained from renewable sources by means of fermentation processes starting from carbohydrates such as sugars and lignocellulose biomass

Methodology Applied
Scientific EffectFermentation: Fermentation

Data Source

PatentUS20250091973A1Process for the production of 1,4-butanediol from renewable sources and polyesters obtained therefrom
Publication Date: 2025.03.20 NOVAMONT SPA

AI summary

The invention relates to a process for the production of 1,4-butanediol comprising the preparation of a fermentation broth comprising 1,4-butanediol from renewable sources and water, separation of a liquid fraction comprising said 1,4-butanediol and water from one or more solid fractions, said liquid fraction comprising 2-pyrrolidone in an amount higher than 80 ppm, one or more passages of the resulting liquid fraction through a bed comprising one or more cation-exchange resins thereby providing an output pH of said liquid fraction from 4 to 2, one or more passages of the resulting liquid fraction through a bed comprising one or more anion-exchange resins thereby providing an output pH of said liquid fraction from 8 to 11, and the distillation of the liquid fraction thereby provided so as to obtain a composition having a concentration of said 1,4-butanediol higher than 99.0% by weight and comprising 2-pyrrolidone in an amount lower than 6 ppm. The resulting composition should exhibit an APHA color value after ageing of less than 30.