Butorphanol Patch Adhesive Layer Composition
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Solution Overview
Problem
Patches containing butorphanol or its pharmaceutically acceptable salts often experience insufficient adhesion to the skin, particularly under warm water or high humidity conditions, necessitating improved skin permeability and adhesion resistance.
Innovation Solution
A patch design incorporating a backing layer and an adhesive layer with a specific blending ratio of rubber-based and silicone-based adhesive bases, along with butorphanol and/or its pharmaceutically acceptable salts, to enhance skin permeability and adhesion, even under challenging conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If rubber-based adhesive base is used to achieve excellent adhesive strength, then adhesion to skin is improved, but adhesion deteriorates under warm water or high humidity conditions
Solution Approach 1:
The patent combines rubber-based adhesive base and silicone-based adhesive base in a specific mass ratio (9.5:0.5 to 1.9:8.1) to create a composite adhesive system. The rubber-based component provides initial adhesive strength, while the silicone-based component maintains adhesion stability under water and humidity conditions, resolving the contradiction between strong adhesion and adhesion reliability.
Solution Approach 2:
The patent optimizes the mass ratio parameters of rubber-based and silicone-based adhesive bases to achieve the desired balance. By adjusting these compositional parameters within specific ranges, the adhesive system achieves both strong initial adhesion and maintained adhesion under challenging environmental conditions.
2Duration of action of stationary object
If patch is designed for long-term skin application, then duration of action is improved, but skin permeability requirement increases
Solution Approach 1:
The patent optimizes the content ratio of butorphanol to adhesive bases within specific ranges to ensure sufficient drug loading for long-term application while maintaining effective skin permeability. This parameter optimization allows the patch to deliver adequate drug amounts over extended periods without compromising permeability.
Solution Approach 2:
The silicone-based adhesive base component contributes to maintaining skin permeability during long-term application, while the rubber-based component ensures prolonged adhesion. The composite system addresses both the extended duration requirement and the permeability maintenance challenge.
3Object-affected harmful factors
If butorphanol content per unit area is reduced, then safety is improved, but skin permeability may be insufficient
Solution Approach 1:
The patent optimizes the butorphanol content parameters within specific ranges (3-20% by mass relative to total adhesive layer mass) to achieve the lowest effective dose that maintains sufficient skin permeability. This parameter optimization ensures safety by minimizing drug content while maintaining therapeutic effectiveness through enhanced permeability from the adhesive base combination.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch achieves superior skin permeability and high-level adhesion with excellent water resistance and moisture resistance, maintaining effective adhesion and drug delivery performance.
Implementation Method 1
the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base
Implementation Method 2
the patch is required to exhibit superior skin permeability of butorphanol
Data Source
AI summary
A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.