Butyrate Triglyceride Composition for Intestinal Bone Health Delivery
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Solution Overview
Problem
Butyric acid and tributyrin have negative sensory qualities such as vomit-like, fecal, and cheesy aromas, making their oral administration difficult, especially in pediatric populations, and there is a need for a food-grade source of butyrate with improved organoleptic properties for maintaining bone health and treating bone disorders.
Innovation Solution
Development of triglycerides containing butyrate moieties with long chain fatty acids, such as 1,3-dibutyryl-2-palmitoylglycerol and 1,3-dibutyryl-2-oleoylglycerol, which have improved odor and taste, providing a dietary source of butyrate for nutritional compositions, dietary supplements, and infant formulas.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If butyric acid or tributyrin is used as a dietary source of butyrate, then bone health is improved, but organoleptic properties deteriorate due to negative sensory qualities
Solution Approach 1:
The patent uses long-chain fatty acid triglycerides as intermediary carriers to deliver butyrate to the intestine. These triglycerides act as mediators that mask the unpleasant sensory qualities of butyrate while maintaining its bone-health benefits through controlled release in the intestinal compartment.
Solution Approach 2:
The patent changes the physical-chemical parameters of butyrate delivery by transitioning from free butyric acid or tributyrin to triglyceride ester forms with long-chain fatty acids. This parameter change fundamentally alters the organoleptic properties from negative to neutral/positive while preserving the butyrate functionality.
2Quantity of substance
If tributyrin is used as a butyrate source, then butyrate delivery is achieved, but gastric lipolysis rapidly degrades its efficacy
Solution Approach 1:
The patent modifies the molecular structure parameters of butyrate carriers by using triglycerides with long-chain fatty acids (C16-C20) instead of short-chain tributyrin. This structural parameter change reduces gastric lipolysis susceptibility while maintaining intestinal delivery efficacy.
Solution Approach 2:
The patent employs triglycerides as temporary carriers that are designed to be stable in the gastric environment but readily degraded in the intestinal environment, releasing butyrate at the target location. This disposable carrier approach ensures reliable butyrate delivery without premature degradation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compounds exhibit low gastric lipolysis and effective delivery of butyric acid to the intestinal compartment, improving bone health and treating bone disorders by enhancing bone density and strength.
Implementation Method 1
Under hydrolysis conditions such as those occurring during digestion, tributyrin is potentially a source of three moles of butyric acid per mole of tributyrin
Implementation Method 2
the compounds exhibit low gastric lipolysis and may provide an effective delivery of butyric acid to the intestinal compartment
Data Source
AI summary
Use of a compound having the formulaor combinations thereof, for use in in maintenance of bone health and/or prevention, and/or treatment of bone disorders associated to unbalanced bone catabolism wherein R1, R2, R3, R4, R5 and R6 are independently a long chain fatty acid having between 16 and 20 carbons.