Butyrylated Cellulose Derivative for Th1 Cell Induction
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Solution Overview
Problem
Existing methods for increasing type 1 helper T cells (Th1) face challenges such as high doses required, restrictive storage and feeding conditions, and impractical administration forms, making them unsuitable for human consumption or widespread use.
Innovation Solution
A Th1-increasing agent containing a cellulose derivative with a specific degree of butyryl substitution and total degree of substitution, which is easily stored and can be incorporated into various food and pharmaceutical forms, allowing for efficient release of butyric acid in the digestive tract.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bacterial cells of lactic acid bacterium are used as Th1 inducer, then Th1 differentiation is promoted, but storage conditions and administration form are restricted
Solution Approach 1:
The invention extracts the essential active component (butyric acid) from the bacterial cell system and incorporates it into a cellulose derivative structure. This allows the therapeutic effect to be maintained while eliminating the need for complex storage and administration conditions associated with live bacterial cells.
Solution Approach 2:
The cellulose derivative acts as an intermediary carrier that delivers butyric acid to the intestinal tract. This mediator approach allows controlled release of the active substance while simplifying storage and administration compared to using live bacterial cells directly.
2Quantity of substance
If high dose of fermented milk or lactic acid bacteria beverage is administered, then sufficient viable bacteria count is achieved, but oral administration becomes painful and diet enjoyment is impaired
Solution Approach 1:
The invention changes the form of administration from live bacteria in fermented milk to a cellulose derivative containing butyric acid. This parameter change allows achieving the same therapeutic effect at much lower doses, making oral administration comfortable and acceptable.
Solution Approach 2:
The cellulose derivative serves as a stable, non-living alternative to perishable fermented milk products. It provides consistent dosing without the variability and large quantities required by bacterial-based products.
3Reliability
If transformed lactic acid bacterium is administered intragastrically, then in vivo production of cytokines is promoted, but storage conditions become restrictive
Solution Approach 1:
The invention extracts butyric acid from the transformed lactic acid bacterium system and incorporates it into a stable cellulose derivative structure. This maintains the cytokine-promoting effect while achieving long-term storage stability at room temperature.
Solution Approach 2:
The invention creates a composite material combining cellulose derivative with butyric acid. This composite provides both the therapeutic effect of butyric acid and the storage stability of cellulose, eliminating the restrictive storage conditions of live bacterial systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cellulose derivative-based Th1-increasing agent effectively increases Th1 cells in the intestinal tract at lower doses, reducing storage and administration constraints, and can be used in a variety of food and pharmaceutical products.
Implementation Method 1
a cellulose derivative-based Th1-increasing agent which efficiently increases Th1 cells in the intestinal tract by releasing butyric acid
Data Source
AI summary
An object is to provide a Th1-increasing agent that can reduce constraints on storage conditions and feeding form and sufficiently increase Th1 at lower doses. A Th1-increasing agent containing a cellulose derivative as an active ingredient, the cellulose derivative having a degree of butyryl substitution of 0.3 or greater and 2.6 or less, and a total degree of substitution of 0.5 or greater and 2.8 or less.