Bacillus Velezensis BV379 Composition for Gut Barrier Integrity
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Solution Overview
Problem
Existing technologies have not effectively addressed gut dysbiosis, which leads to gastrointestinal disorders and systemic inflammation by weakening the intestinal epithelial barrier, allowing microbial translocation and immune system dysregulation.
Innovation Solution
The use of Bacillus velezensis strain BV379, in the form of spores, cells, or metabolites, to restore gut microbiome balance by inhibiting pathogenic bacteria and promoting beneficial microbes, enhancing intestinal barrier integrity, and supporting digestive and immune health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the intestinal epithelial barrier is weakened, then microbial translocation and immune system dysregulation occur, but gut permeability increases leading to gastrointestinal disorders and systemic inflammation
Solution Approach 1:
The patent introduces Bacillus velezensis strain BV379 as an intermediary probiotic that mediates between the intestinal barrier and harmful factors. The strain produces bioactive molecules including macrolactins that actively reinforce barrier integrity while reducing permeability, thus resolving the contradiction between maintaining barrier strength and preventing harmful microbial translocation
Solution Approach 2:
The patent utilizes changes in physiological parameters through probiotic intervention. By administering Bacillus velezensis, the intestinal environment undergoes parameter changes including reduced permeability, enhanced barrier function, and modulated immune response, transforming the gut environment from a permeable state to a protected state
2Reliability
If pathogenic bacteria are present in the gut, then gastrointestinal disorders occur, but the gut microbiome becomes unbalanced leading to dysbiosis
Solution Approach 1:
The patent applies the principle of converting harm into benefit by using Bacillus velezensis to transform a harmful pathogenic environment into a beneficial one. The probiotic strain produces antimicrobial substances and bioactive molecules that inhibit pathogenic bacteria while promoting beneficial microbes, thus converting a dysbiotic state into a balanced microbiome
Solution Approach 2:
The patent employs self-service through the probiotic's ability to autonomously restore microbiome balance. Bacillus velezensis strain BV379 self-regulates the gut environment by producing bioactive molecules that selectively inhibit pathogens and promote beneficial bacteria, enabling the system to correct its own dysbiosis without external intervention
3Reliability
If the intestinal epithelial barrier is compromised, then microbial translocation occurs, but this leads to increased inflammation and immune system dysregulation
Solution Approach 1:
The patent positions Bacillus velezensis as an intermediary that acts between the barrier and the immune system. The strain produces bioactive molecules including macrolactins that mediate communication between the intestinal barrier and immune cells, reducing inflammation and preventing immune dysregulation while maintaining barrier integrity
Solution Approach 2:
The patent implements feedback mechanisms where the probiotic continuously monitors and regulates the intestinal environment. Bacillus velezensis produces anti-inflammatory molecules in response to barrier compromise, creating a feedback loop that actively reduces inflammation and prevents immune system dysregulation while maintaining barrier function
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Bacillus velezensis strain BV379 effectively reduces gut permeability, supports gut microbiota balance, and enhances immune health by secreting bioactive molecules like macrolactins, thereby reducing gastrointestinal symptoms and systemic inflammation.
Implementation Method 1
Bacillus velezensis strain BV379 effectively reduces gut permeability, supports gut microbiota balance, and enhances immune health by secreting bioactive molecules like macrolactins
Implementation Method 2
The strain or progeny thereof is heat-treated, filtered to remove viable cells, or both
Implementation Method 3
BV379 cells, spores, and/or metabolites are provided. The strain or progeny thereof may be in a spray-dried or lyophilized form
Implementation Method 4
BV379 cells, spores, and/or metabolites are provided. The strain or progeny thereof may be in a spray-dried or lyophilized form
Data Source
AI summary
A spore-forming Bacillus species, and more particularly, a Bacillus velezensis strain identified as BV379 is provided. Compositions comprising BV379 and methods of using the same are also provided.