Bypass-Controlled Analyte Separation for Precise Trap Timing

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Solution Overview

Problem

Existing separation systems suffer from contamination, inefficiency, and complexity, particularly when dealing with small quantities of analytes like N2, and often require multiple detectors and complex configurations, leading to potential modes of failure and inaccurate measurements.

Innovation Solution

A system with a bypass line that allows continuous monitoring of analyte presence using a single analyser to control a separator, ensuring precise activation and deactivation based on real-time measurements, reducing the need for additional detectors and manual optimization.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a separator is used to separate analyte from sample, then measurement accuracy is improved, but device complexity increases

Engineering Contradiction:
Improvemeasurement accuracyVSAvoiddevice complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines the separator and analyser into a single integrated system where the analyser is positioned downstream of the separator within the same device architecture. This integration reduces the number of separate components and interconnections needed, thereby reducing device complexity while maintaining measurement accuracy through the separator function.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The analyser serves dual functions: it analyzes the separated analyte downstream and also provides feedback control signals to the controller that regulates the separator operation. This multi-functionality reduces the need for additional dedicated control components, simplifying the overall device while preserving measurement precision.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Productivity

If manual optimization is used for separation timing, then system simplicity is maintained, but productivity decreases

Engineering Contradiction:
Improveseparation efficiencyVSAvoidcontrol system complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent implements a feedback control loop where the analyser continuously monitors the analyte concentration and sends control signals back to the controller, which automatically adjusts the separator operation timing. This automated feedback mechanism eliminates manual optimization needs, improving productivity while the self-regulating nature of the feedback loop prevents excessive complexity.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system uses its own analyser to provide the control signals needed for separator operation optimization. The analyser's measurements directly inform the controller's timing adjustments, allowing the system to self-optimize without external intervention or complex external control systems, thereby improving productivity with minimal added complexity.

Inventive Principle:
Principle #25Self-service

3Measurement precision

If separator is activated continuously, then separation completeness is improved, but analyte loss increases

Engineering Contradiction:
Improveseparation completenessVSAvoidanalyte loss
Core Design Contradiction:
Measurement precisionVSLoss of substance

Solution Approach 1:

The analyser detects the presence and concentration of analyte before the separator is activated. This preliminary detection allows the controller to activate the separator only when analyte is present and at appropriate concentrations, ensuring complete separation when needed while avoiding unnecessary activation that would cause analyte loss, thus improving separation completeness without increasing substance loss.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The separator activation is made dynamic and adaptive based on real-time analyser feedback. The controller continuously adjusts separator operation timing and intensity according to the analyte concentration signals received from the analyser, enabling complete separation when analyte is present while minimizing or eliminating separation activity when analyte is absent or below threshold levels, thereby preventing analyte loss while maintaining separation completeness.

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This system improves separation timing, reduces contamination, and enhances measurement accuracy by automating the trapping procedure, allowing efficient separation of analytes like N2, CO2, CO, SO2, and H2, even in small quantities, while minimizing sample waste and system complexity.

Implementation Method 1

a bypass line configured to provide a first fraction of the sample to the analyser for measurement without passing through the separator

Methodology Applied
Scientific EffectGas flow:

Implementation Method 2

a separator configured to separate the analyte from the sample; Some separation processes exploit differences in chemical properties and/or physical properties (e.g. boiling point, melting point, or other chemical properties) between the constituents of a mixture

Methodology Applied
Scientific EffectSeparation process:

Data Source

PatentUS12618810B2System for separating an analyte from a sample
Publication Date: 2026.05.05 THERMO FISHER SCI BREMEN
  • US12618810B2 patent drawing
  • US12618810B2 patent drawing
  • US12618810B2 patent drawing

AI summary

A system comprises a separator that separates an analyte from the sample, an analyser, downstream of the separator, configured to obtain measurements indicative of a quantity of the analyte in the sample. A bypass line provides a first fraction of the sample to the analyser for measurement without passing through the separator. A controller receives a measurement obtained by the analyser on the first fraction of the sample, the measurement indicating that the first fraction of the sample received via the bypass line comprises a threshold quantity of the analyte. Activation of the separator is based on the received measurement. A second fraction of the sample is provided to the analyser without passing through the bypass line such that the first fraction of the sample arrives at the analyser before the second fraction of the sample arrives at the separator.