High Boiling Point Solvent Cadaverine Purification
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Solution Overview
Problem
Current methods for purifying bio-based cadaverine from cadaverine salt compositions face challenges due to involatile impurities, resulting in low recovery yields and contamination, requiring high heating temperatures and long evaporation/distillation times.
Innovation Solution
The method involves adding high boiling point solvents to the evaporation/distillation system to improve fluidity, allowing for lower heating temperatures and shorter times while maintaining or improving cadaverine recovery yields, and includes the use of solvents with boiling points above 185 °C and solvents that are unreactive with cadaverine.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If traditional evaporation/distillation is used to purify cadaverine from aqueous composition, then cadaverine can be separated, but the process requires high heating temperature and long time due to involatile impurities, resulting in low recovery yield and contamination
Solution Approach 1:
A solvent extraction step is introduced as an intermediary process between the crude cadaverine solution and the final distillation. The solvent selectively extracts cadaverine from the aqueous phase, separating it from involatile impurities before distillation. This pre-separation reduces the burden on the distillation process, allowing it to operate more efficiently with lower temperature and shorter time, thereby resolving the contradiction between achieving high purity and reducing processing time
Solution Approach 2:
The invention changes the physical parameters of the system by introducing a solvent that alters the volatility characteristics of cadaverine. By adjusting the solvent-to-cadaverine ratio and performing extraction at controlled temperatures, cadaverine is transferred to the organic phase where it can be more easily distilled. This parameter change enables faster separation with reduced thermal stress, addressing both the time consumption and purity requirements
2Manufacturing precision
If traditional evaporation/distillation is used to purify cadaverine from aqueous composition, then cadaverine can be separated, but the process requires high heating temperature, resulting in increased energy consumption and potential decomposition
Solution Approach 1:
The solvent extraction step acts as an energy-saving intermediary by performing the initial separation of cadaverine from the aqueous matrix at lower temperatures. This pre-concentration and purification step reduces the amount of water and impurities that would otherwise require high energy input for removal during distillation, thereby lowering overall energy consumption while maintaining high purity output
Solution Approach 2:
By changing the phase distribution of cadaverine through solvent extraction, the invention transforms the separation problem from a high-energy thermal process to a lower-energy liquid-liquid extraction followed by a simplified distillation. This parameter change in the separation mechanism significantly reduces the heating energy required while achieving the same or better purity levels
3Quantity of substance
If high heating temperature and long evaporation time are used to purify cadaverine, then some cadaverine can be recovered, but decomposition occurs and recovery yield remains low
Solution Approach 1:
The solvent extraction step serves as a protective intermediary that separates cadaverine from the aqueous environment and involatile impurities before thermal processing. This pre-separation protects cadaverine from decomposition by removing catalysts and impurities that would promote thermal degradation during evaporation, thereby increasing recovery yield while minimizing harmful decomposition effects
Solution Approach 2:
The invention changes the thermal processing parameters by performing extraction at moderate temperatures followed by a simplified distillation of a more concentrated solution. This parameter change reduces the total thermal exposure time and intensity, preventing cadaverine decomposition and improving recovery yield
4Device complexity
If traditional evaporation/distillation is used without solvent addition, then the process is simpler, but fluidity is poor and cadaverine quality is compromised due to involatile impurities
Solution Approach 1:
The solvent acts as a mediating substance that improves the fluidity and separability of cadaverine from the aqueous composition. By introducing this intermediate extraction step, the process achieves better mass transfer and phase separation, resulting in higher cadaverine quality. The added complexity of solvent handling is offset by the significant improvement in product quality and the simplification of the subsequent distillation step
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly enhances cadaverine recovery yields and quality by reducing heating temperatures and times, minimizing decomposition, and effectively managing involatile impurities, especially in industrial-scale processes.
Implementation Method 1
obtain cadaverine from evaporation or distillation of the aqueous cadaverine composition
Implementation Method 2
obtain cadaverine from evaporation or distillation of the aqueous cadaverine composition
Implementation Method 3
the evaporation or distillation is done at a heating temperature of 80 °C to 180 °C
Implementation Method 4
the evaporation or distillation is subjected to a pressure lower than the ambient pressure
Data Source
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AI summary
One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising obtaining cadaverine from evaporation or distillation of the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed; wherein the one or more solvents comprise at least one or more high boiling point (HBP) solvents. In certain embodiments, cadaverine may be evaporated/distilled at an unexpectedly lower heating temperature for an unexpectedly shorter heating time to provide a desired yield. Because cadaverine may decompose at high temperature, the unexpectedly lower heating temperature and unexpectedly shorter heating time decrease the undesired cadaverine decomposition. The methods disclosed herein provides unexpected high recovery rate (~100%) in the evaporation/distillation of cadaverine at a larger scale at a lower heating temperature compared to conventional distillation methods. Thus, the method disclosed herein will be highly appreciated in the industrial production of cadaverine.