Calcified Tissue Substitute With Multi-Calcium Salt Gradient
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Solution Overview
Problem
Current bone substitutes lack sufficient osteoconductivity and osteoinductivity, and nacre's rapid degradation limits its application as an implantable or injectable bone substitute due to its rapid resorption rate.
Innovation Solution
A calcified tissue substitute is developed using a multi-calcium salt resorption gradient that induces gradual pore formation, comprising ground nacre, monocalcium phosphate, and water to produce brushite, which is then reacted with disodium hydrogen phosphate to create a porous structure that promotes new bone formation without compromising mechanical properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nacre is used as a bone substitute, then osteoinductivity is improved, but degradation rate becomes too rapid
Solution Approach 1:
The patent creates a composite material combining nacre particles with calcium phosphate cement matrix. The nacre provides osteoinductive properties while the calcium phosphate cement provides structural support and controlled degradation. This composite approach allows the material to exhibit both high osteoinductivity and controlled degradation rate, resolving the contradiction between these two properties.
Solution Approach 2:
The patent modifies the degradation rate by changing the chemical composition parameters of the calcium phosphate cement matrix and the ratio of nacre to cement. By adjusting these parameters, the degradation rate is controlled to match the bone regeneration rate, preventing rapid resorption while maintaining osteoinductivity.
2Reliability
If porous structure is created in bone substitute, then osteoconductivity is improved, but mechanical strength is reduced
Solution Approach 1:
The patent utilizes the inherent porosity of the calcium phosphate cement matrix to provide osteoconductivity. The porous structure allows bone ingrowth and vascularization while the cement matrix maintains sufficient mechanical strength. The porosity is optimized to balance osteoconductivity and mechanical properties.
Solution Approach 2:
The composite structure of nacre particles embedded in calcium phosphate cement provides both porous architecture for osteoconductivity and structural integrity for mechanical strength. The interfacial bonding between nacre and cement matrix enhances overall strength while maintaining porosity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The calcified tissue substitute achieves controlled resorption and enhanced osteoconductivity, supporting mechanical strength during early stages of tissue repair and facilitating new bone formation, outperforming traditional calcium phosphate-based products in terms of biodegradation and osteoinductive capabilities.
Implementation Method 1
reacting ground nacre, monocalcium phosphate, and water to produce brushite
Implementation Method 2
reacting ground nacre with the ground brushite in disodium hydrogen phosphate solution
Data Source
AI summary
The invention relates to a calcified tissue substitute and methods of manufacturing and use related thereto. The methods for manufacturing a calcified tissue substitute include reacting ground nacre, monocalcium phosphate, and water to produce brushite; grinding the brushite; reacting ground nacre with the ground brushite disodium hydrogen phosphate solution. Methods for repairing and/or strengthening a calcified tissue in need thereof are provided, as well as a delivery device for delivering the calcified tissue substitute.