Calcium Preparation Stabilization via Citric and Phosphoric Acid Complexes
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Solution Overview
Problem
There is a need for a stable and less bitter calcium preparation that is transparent and stable at high concentrations, particularly in a wide pH range higher than slightly acidic, as existing techniques fail to provide such a solution effectively.
Innovation Solution
An aqueous preparation of calcium comprising water, calcium, a compound of Formula I (citric acid structure), and a compound of Formula II (phosphoric acid structure), where 98% or more of the calcium is in a non-ionic form, forming a complex that binds with these compounds and forms colloidal particles, maintaining transparency and stability at pH values ranging from 4 to 13.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium is dissolved in water to create a calcium solution, then calcium availability is improved, but the solution becomes unstable and forms precipitates over time
Solution Approach 1:
The patent introduces citric acid and phosphoric acid as intermediary substances that mediate between calcium ions and water. These intermediaries form stable complexes with calcium, preventing direct precipitation and maintaining solution stability and transparency over time.
Solution Approach 2:
The patent creates a composite calcium preparation system containing calcium ions, citric acid, phosphoric acid, and water. This composite formulation leverages the synergistic effects of multiple components to achieve enhanced stability and prevent precipitation that cannot be achieved with simple calcium solutions.
2Quantity of substance
If calcium concentration is increased to provide sufficient calcium intake, then nutritional effectiveness is improved, but bitterness increases and oral ingestion becomes difficult
Solution Approach 1:
The patent changes the chemical parameters of the calcium solution by introducing citric acid and phosphoric acid. This alters the taste profile and reduces bitterness, enabling higher calcium concentrations to be orally ingested without the unpleasant bitter taste that would otherwise prevent continuous consumption.
3Ease of manufacture
If pH is adjusted to improve calcium solubility, then dissolution rate is improved, but solution stability deteriorates at extreme pH values
Solution Approach 1:
The patent optimizes the pH parameter within a specific range (pH 4-13) and introduces citric acid and phosphoric acid that stabilize calcium solubility across this wide pH range. This allows efficient calcium dissolution while maintaining solution stability even at extreme pH values within the specified range.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a stable calcium preparation that is transparent and stable at high concentrations, preventing precipitate formation and maintaining transparency over time, even at extreme pH values, making it suitable for oral ingestion and various applications.
Implementation Method 1
wherein 98% or more of the calcium is in non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of Formula I and/or the compound of Formula II
Implementation Method 2
at least a part of the complex forms colloidal particles
Data Source
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AI summary
A stable calcium preparation in solution form even at high concentration is provided. As such a calcium preparation, an aqueous preparation of calcium is provided, wherein the aqueous preparation of calcium includes, for example, water, calcium, a compound of Formula I, and a compound of Formula II as constituent elements, most of the calcium is in non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of Formula I and/or the compound of Formula II in a state that basic structures of these compounds are kept, at least a part of the complex forms colloidal particles, and the aqueous preparation of calcium is a transparent aqueous preparation having a pH equal to or higher than that of slightly acid; wherein, A1, A2, A3, A4, A5 and A6 are independently O- or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist.