Calcium HMB Protein Composition Sequestration Stability
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Solution Overview
Problem
Existing nutritional compositions containing calcium beta-hydroxy-beta-methylbutyrate (HMB) and protein are unstable and unsuitable for individuals with diabetes or chronic kidney dysfunction due to high levels of soluble divalent calcium, leading to issues like viscosity problems and electrolyte overload.
Innovation Solution
The use of sequestered or ion-exchanged calcium HMB, which reduces the amount of soluble divalent calcium, eliminating the need for traditional organic acid salts and minimizing electrolyte levels, thereby stabilizing the compositions and making them safe for individuals with metabolic disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional organic acid salts (sodium citrates, potassium citrates, sodium phosphates, potassium phosphates) are used as protein stabilizers in calcium HMB and protein nutritional compositions, then the compositions can be stabilized against protein aggregation and precipitation, but the compositions contain high levels of electrolytes (sodium, potassium, phosphorus) which are unsuitable for individuals with diabetes or chronic kidney dysfunction
Solution Approach 1:
The patent removes traditional organic acid salt stabilizers (containing sodium, potassium, phosphorus) from the formulation and replaces them with calcium acetate and calcium lactate, which provide the necessary protein stabilization function while significantly reducing harmful electrolyte levels
Solution Approach 2:
The patent changes the chemical composition parameters by substituting multi-electrolyte organic acid salts with calcium-based stabilizers, thereby altering the electrolyte profile from high sodium/potassium/phosphorus to low electrolyte levels with controlled calcium content
2Quantity of substance
If soluble divalent calcium species are present in liquid nutritional compositions containing protein, then the nutritional value and bioavailability are improved, but the compositions become unstable with increased viscosity, phase separation, and protein aggregation leading to sedimentation and gelation
Solution Approach 1:
The patent modifies the calcium species parameters by using calcium acetate and calcium lactate instead of highly soluble calcium sources, controlling the solubility and reactivity of calcium to maintain stability while preserving nutritional value
Solution Approach 2:
The patent introduces calcium acetate and calcium lactate as intermediary compounds that mediate between the need for soluble calcium and the need for protein stability, providing a balanced formulation that avoids direct harmful interactions between calcium and protein
3Adaptability or versatility
If calcium HMB is combined with protein in liquid nutritional formulations to enhance muscle building, then the anabolic effects are improved, but the formulations become unstable with protein precipitation and sedimentation over time
Solution Approach 1:
The patent extracts the instability-causing components (traditional organic acid salts and excessive soluble calcium) from the formulation while retaining the beneficial muscle-building components (calcium HMB and protein), achieving stability without sacrificing efficacy
Solution Approach 2:
The patent creates a composite stabilization system using calcium acetate and calcium lactate in combination with controlled calcium HMB and protein levels, forming a stable multi-component formulation that maintains both functionality and physical stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The approach results in stable nutritional compositions that can be used by individuals with diabetes or chronic kidney dysfunction to build and maintain muscle mass without electrolyte overload, with reduced levels of sodium, potassium, and phosphorus, enhancing their safety and effectiveness.
Implementation Method 1
calcium beta-hydroxy-beta-methylbutyrate that has been treated by sequestration (chelation)
Implementation Method 2
treated by sequestration (chelation), with an ion exchange resin/polymer, or both
Data Source
AI summary
Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.