Calcium Microparticles for Alveolar Bone Regeneration

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Solution Overview

Problem

Current methods for regenerating alveolar bone tissue around dental implants or roots, such as ultrasonic therapy, are inefficient in completely removing infected granulation tissue and require extended treatment periods, leading to patient inconvenience.

Innovation Solution

The use of calcium-containing microparticles, specifically obtained by crushing carbonate apatite clumps and sieving to achieve particle sizes between 300 µm and 500 µm, which are blown into the gap between the implant and alveolar bone, combined with laser irradiation to degenerate and fix the microparticles, facilitating faster bone tissue regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of time

If ultrasonic therapy is used to promote bone tissue regeneration, then the treatment period can be shortened to a certain degree, but further shortening of the treatment period is desired

Engineering Contradiction:
Improvetreatment periodVSAvoidbone tissue regeneration efficiency
Core Design Contradiction:
Loss of timeVSProductivity

Solution Approach 1:

The patent combines multiple therapeutic approaches into a single integrated treatment: ultrasonic vibration therapy is merged with calcium-containing microparticle application and laser irradiation. This combination allows the treatment to achieve multiple effects simultaneously - mechanical stimulation for osteogenesis, biological activation through microparticles, and thermal/photostimulation from laser - thereby further shortening the treatment period beyond what ultrasonic therapy alone can achieve

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent uses composite material consisting of calcium-containing microparticles (such as hydroxyapatite or beta-tricalcium phosphate) that serve multiple functions: they act as osteoinductive agents, provide structural scaffold for bone regeneration, and enhance the effects of ultrasonic and laser treatments. This composite approach accelerates bone tissue regeneration more effectively than single-modality treatments

Inventive Principle:
Principle #40Composite materials

2Reliability

If a longer treatment period is required to regenerate bone tissue between implant and alveolar bone, then adequate immobilization of implant is achieved, but patient is subjected to inconveniences and burdens

Engineering Contradiction:
Improveimplant immobilizationVSAvoidtreatment period
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies calcium-containing microparticles to the treatment site before the bone regeneration process fully begins. These microparticles are positioned on the implant surface and in the gap between implant and alveolar bone in advance, where they release calcium ions and provide osteoinductive signals that prepare the site for accelerated bone growth, thereby achieving reliable immobilization in a shorter time frame

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent changes the chemical and physical parameters of the treatment site by introducing calcium-containing microparticles that alter the local environment. The microparticles modify the biochemical composition (releasing calcium and phosphate ions), change the surface properties of the implant, and create a more favorable environment for osteoblast activity, thereby accelerating bone regeneration while maintaining reliable implant immobilization

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method significantly shortens the treatment period by promoting bone tissue regeneration, enhancing bonding strength between the implant and alveolar bone, and reducing the risk of bacterial growth by complete removal of infected granulation tissue.

Implementation Method 1

irradiating the surface and the microparticles with laser light in a state in which the microparticles are adhered to at least a portion of the surface to fix at least a portion of the microparticles to the surface and degenerate the infected granulation tissue remaining in the gap

Methodology Applied
Scientific EffectLaser heating: Laser

Implementation Method 2

A known example of a conventional method consists of the application of ultrasonic vibrations to the treatment site (treated area) to promote regeneration of bone tissue

Methodology Applied
Scientific EffectUltrasonic vibration: Ultrasonic Vibration

Data Source

PatentEP2839848B1Calcium-containing microparticles used to regenerate alveolar bone
Publication Date: 2019.12.25 BIO MAP
  • EP2839848B1 patent drawingFigure 1
  • EP2839848B1 patent drawingFigure 2
  • EP2839848B1 patent drawingFigure 3

AI summary

A method for regenerating alveolar bone in which bone tissue is regenerated in the gap between an implant or dental root and alveolar bone, which comprises a procedure consisting of making an incision in the gingiva surrounding an implant or dental root embedded in alveolar bone, blowing a first air into the gap between the implant or dental root and the alveolar bone to remove a portion of infected granulation tissue present in the gap, and irradiating the gap with laser light to degenerate the infected granulation tissue remaining in the gap, followed by blowing a second air containing microparticles having calcium as a constituent thereof and water into the gap to remove the degenerated infected granulation tissue and fill in the gap with the wet microparticles.