Calcium Phosphate Ceramic with Trace Elements for Bone Repair
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Solution Overview
Problem
Current bone filling materials used clinically are osteoconductive but not osteoinductive, leading to a low success rate, and the addition of bone growth factors like BMP is expensive and associated with adverse effects.
Innovation Solution
A calcium phosphate ceramic with trace elements such as Mg, Sr, Na, and Fe, which does not require artificial incorporation of element ions, is developed. This ceramic is derived from biological waste and has a biphasic or triphasic composition, including hydroxyapatite and β-tricalcium phosphate, to promote osteoinductivity and osteogenesis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bone growth factors such as BMP are added to bone filling materials to make them osteoinductive, then osteoinductivity is improved, but cost increases and adverse events occur
Solution Approach 1:
The patent changes the chemical composition parameters by incorporating specific trace elements (Mg: 0.1-5 wt%, Sr: 0.1-5 wt%, Na: 0.1-5 wt%, Fe: 0.1-5 wt%) into the calcium phosphate ceramic structure. This compositional modification enables the material to exhibit osteoinductive properties through trace element-mediated biological responses, replacing the need for protein-based growth factors and avoiding their associated adverse effects.
2Reliability
If multiple types of trace elements are incorporated into bone filling materials, then osteoinductivity is improved, but manufacturing complexity increases and impurity control becomes difficult
Solution Approach 1:
The patent combines multiple trace element incorporation steps into a single sintering process. By adding magnesium carbonate, strontium carbonate, sodium carbonate, and iron oxide simultaneously to the calcium phosphate precursor mixture and sintering at 900-1100°C, all trace elements are incorporated in one operation, simplifying the manufacturing process and ensuring uniform distribution without sequential processing complexity.
Solution Approach 2:
The patent creates a composite calcium phosphate ceramic material that integrates multiple functional components: hydroxyapatite/β-tricalcium phosphate base structure plus trace elements (Mg, Sr, Na, Fe). This composite approach allows each component to contribute specific properties while maintaining overall material stability and controllable composition within defined ranges.
3Reliability
If high concentration of single ion is added to trigger osteoinduction, then osteoinductivity is improved, but biological toxicity increases
Solution Approach 1:
The patent optimizes the concentration parameters of trace elements to achieve osteoinduction at safe levels. By specifying narrow ranges (0.1-5 wt% for each element) and balancing multiple elements simultaneously, the material achieves threshold effects for osteoinduction while maintaining concentrations below toxic thresholds, leveraging synergistic interactions among elements.
Solution Approach 2:
The patent uses a multi-element composite approach where Mg, Sr, Na, and Fe work synergistically. Each element contributes to osteoinduction through different mechanisms (Mg for crystal structure stability, Sr for osteoblast differentiation, Na for ion exchange, Fe for angiogenesis), allowing lower individual concentrations while achieving cumulative osteoinductive effects that reduce toxicity risks.
Data Source
AI summary
The present invention provides a calcium phosphate ceramic with trace elements, wherein a main component of the calcium phosphate ceramic is selected from a group consisting of hydroxyapatite (HA), α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), tetracalcium phosphate (TTCP) and any combination thereof; the calcium phosphate ceramic comprises various trace elements, at least including Mg, Sr, Na and Fe. The calcium phosphate ceramic is high biocompatible and non-cytotoxic, meanwhile demonstrates extraordinary features of osteoinductivity, osteoconductivity, osteogenesis activity and achieves the purpose of bone repair.