Calcium Phosphate Biomaterial Blood Coagulation Bone Regeneration
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Solution Overview
Problem
Current biomaterials for bone reconstruction, particularly for large defects, are limited by the need for autologous grafts, high costs, and complications associated with cell culture and handling, which do not achieve the same results as bone grafting and struggle with large defect reconstruction.
Innovation Solution
A biomaterial based on calcium phosphate, specifically hydroxyapatite or biphasic calcium phosphate, impregnated with a coagulating agent to inhibit blood coagulation and promote osteogenesis, allowing for a simple, cost-effective, and efficient bone reconstruction process without the need for extensive cell culture or sampling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autologous bone grafting is used for bone reconstruction, then bone consolidation quality is improved, but the quantity of available bone is limited and post-operative complications occur
Solution Approach 1:
The patent uses coagulated blood as an intermediary substance that promotes bone reconstruction. The blood coagulum serves as a mediator between the calcium phosphate support and bone formation, providing growth factors and a scaffold that stimulates osteogenesis without requiring large quantities of autologous bone
Solution Approach 2:
The patent changes the chemical parameters of the implantation site by introducing calcium chloride solution, which modifies the ionic environment to promote blood coagulation and subsequent bone formation. This parameter change enables bone reconstruction without relying on the quantity of available autologous bone
2Reliability
If biomaterials are combined with mesenchymal stem cells for bone reconstruction, then bone regeneration is promoted, but the process becomes cumbersome and expensive
Solution Approach 1:
The patent extracts the essential function of bone regeneration promotion from the complex cell culture process. By using coagulated blood instead of cultured mesenchymal stem cells, the invention removes the cumbersome and expensive cell selection and culture steps while maintaining bone regeneration effectiveness
Solution Approach 2:
The patent replaces expensive, long-term cell culture processes with a simpler, immediate blood coagulation approach. The coagulated blood provides transient but effective osteogenic stimulation without requiring expensive infrastructure for cell maintenance
3Adaptability or versatility
If blood is taken from the recipient and mixed with the support for implant preparation, then bone reconstruction is enabled, but the process becomes complex and sources contamination
Solution Approach 1:
The patent performs preliminary impregnation of the calcium phosphate support with calcium chloride solution before implantation. This preliminary action prepares the support to promote blood coagulation in situ, eliminating the need for complex pre-mixing procedures and reducing contamination risks
Solution Approach 2:
The calcium chloride solution serves as an intermediary that facilitates blood coagulation directly at the implantation site. This mediator enables bone reconstruction capability while simplifying the manufacturing process by eliminating complex mixing steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biomaterial effectively promotes the rapid formation of high-quality, vascularized bone tissue with improved biocompatibility and reduced post-operative complications, facilitating the reconstruction of both small and large bone defects.
Implementation Method 1
coagulated blood promotes bone reconstruction
Implementation Method 2
The calcium phosphate support is then resorbed by osteoclasts
Data Source
Figure 1A~1B
Figure 1C~1D
Figure 2
AI summary
The invention relates to a biomaterial containing calcium phosphate, in particular hydroxyapatite or a material containing hydroxyapatite, such as biphasic calcium phosphates and calcium phosphate cements, and to the use thereof for the production of an implant or for fitting a prosthesis for the purpose of bone tissue regeneration.