Calcium Phosphate Glass Composition for Dentin Tubule Sealing

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing compositions for tooth remineralization do not effectively protect and minimize irregularities and defects on dentin surfaces, leading to tooth sensitivity and periodontal disease.

Innovation Solution

A composition comprising calcium phosphate glass and aqueous silica sol is applied to dentin surfaces, forming a gel layer that seals exposed tubules and, upon dissolution, remineralizes with hydroxyapatite or calcium phosphate, sealing the tubules permanently.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional remineralization compositions are used, then some remineralization effect is achieved, but dentin surfaces are not completely protected and irregularities and defects are not significantly minimized

Engineering Contradiction:
Improveprotection of dentin surfacesVSAvoidsurface irregularities and defects
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The invention uses a composite material system consisting of calcium phosphate glass particles dispersed in an aqueous colloidal silica solution. This composite provides both the remineralization function (through calcium phosphate release) and the surface sealing function (through silica gel layer formation), achieving complete dentin protection and significant minimization of surface irregularities that conventional single-material compositions could not achieve.

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The calcium phosphate glass in the composition has a porous structure that enables controlled release of calcium and phosphate ions to the dentin surface. This porous material design enhances the remineralization efficiency while allowing the formation of a uniform sealing layer that addresses surface irregularities and defects effectively.

Inventive Principle:
Principle #31Porous materials

2Object-affected harmful factors

If a gel layer is formed to seal exposed tubules, then tooth sensitivity is reduced, but the composition requires specific formulation parameters to achieve complete and permanent sealing

Engineering Contradiction:
Improvetooth sensitivityVSAvoidcomposition formulation
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The invention specifies precise formulation parameters including 5-20 wt% calcium phosphate glass particles, colloidal silica concentration of 10-40 wt%, pH range of 3-7, and particle size distribution with D10 of 0.5-5 μm and D90 of 5-20 μm. These controlled parameter changes ensure the gel layer forms with appropriate properties for complete and permanent tubule sealing, effectively reducing tooth sensitivity while maintaining manageable composition complexity.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Reduces tooth sensitivity and halts periodontal disease by sealing dentin tubules and remineralizing the tooth surface, effectively minimizing surface irregularities.

Implementation Method 1

forming a gel layer that seals exposed tubules

Methodology Applied
Scientific EffectGelation: Gel

Implementation Method 2

the calcium phosphate glass dissolves in the oral environment, and its ionic components are remineralized

Methodology Applied
Scientific EffectDissolution: Solvation

Implementation Method 3

aqueous silica sol...forming a gel layer containing very fine glass particles

Methodology Applied
Scientific EffectAdsorption: Adsorption

Data Source

PatentEP3966175B1Composition for the remineralization of teeth
Publication Date: 2025.12.24 FERTON HOLDING SA
  • EP3966175B1 patent drawingFigure 1
  • EP3966175B1 patent drawingFigure 2~4
  • EP3966175B1 patent drawingFigure 5

AI summary

The present invention relates to a composition for the remineralization of teeth and to the use thereof. The composition comprises calcium phosphate (CaP) glass, and aqueous silica sol.