Hydrothermal Calcium Phosphate Needle Morphology for Bone Repair
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Solution Overview
Problem
Current calcium phosphate materials for bone grafts lack effective osteoinductive properties, which hinder rapid and profound bone formation, especially in non-osseous sites, and are difficult to introduce and implant effectively.
Innovation Solution
A method involving hydrothermal treatment of sintered biphasic calcium phosphate materials to transform surface grains into needles, increasing specific surface area and protein adsorption capacity, resulting in enhanced osteoinductive properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium phosphate materials are used for bone grafts, then bone substitution is achieved, but osteoinductive properties are insufficient for rapid and profound bone formation
Solution Approach 1:
The patent applies parameter changes by modifying the surface morphology of calcium phosphate particles through controlled precipitation conditions. By adjusting parameters such as pH, temperature, and precipitation time, the invention transforms spherical particles into rod-shaped particles with enhanced surface area and osteoinductive properties, thereby resolving the contradiction between material reliability and bone formation productivity
Solution Approach 2:
The invention utilizes porous material structures by creating hierarchical porosity within the calcium phosphate rods. The internal porous structure increases surface area for protein adsorption and cell interaction while maintaining structural integrity, thus improving osteoinductive properties without compromising mechanical stability during bone formation
2Stability of the object's composition
If conventional calcium phosphate materials are used, then material stability is maintained, but protein adsorption capacity is insufficient for osteoinduction
Solution Approach 1:
The invention changes physical parameters of the calcium phosphate material by controlling the precipitation process to form rod-shaped particles with aspect ratios of 2:1 to 10:1. This morphological transformation increases surface area by 2-5 times compared to spherical particles while maintaining chemical stability, thereby enhancing protein adsorption capacity without sacrificing material stability
Solution Approach 2:
The patent transitions from zero-dimensional spherical particles to one-dimensional rod-shaped structures, adding dimensional complexity to the material architecture. This dimensional change dramatically increases surface area and creates hierarchical pore structures that enhance protein adsorption capacity while preserving the fundamental chemical stability of hydroxyapatite and beta-tricalcium phosphate
3Reliability
If bone graft material is implanted, then bone repair is achieved, but implantation difficulty persists especially in non-osseous sites
Solution Approach 1:
The invention applies segmentation by dividing the bone graft material into discrete rod-shaped particles with optimized size distributions. The rod shape and controlled particle size (50-500 micrometers) enable easy handling, mixing with bone marrow aspirate, and injection through syringes into non-osseous sites, thereby improving implantation ease while maintaining bone repair effectiveness
Solution Approach 2:
The patent utilizes hydraulic principles by formulating the rod-shaped calcium phosphate particles into injectable suspensions. The optimized particle morphology and size distribution enable smooth flow through catheters and syringes, allowing minimally invasive implantation into non-osseous sites such as soft tissues and muscles, thus resolving the implantation difficulty without compromising bone repair effectiveness
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The treated calcium phosphate materials exhibit significantly improved osteoinductive behavior, facilitating faster and more extensive bone formation, and can be easily implanted as a scaffold for bone repair in both osseous and non-osseous sites.
Implementation Method 1
subjecting the sintered biphasic calcium phosphate starting material to a hydrothermal treatment at a temperature equal to or higher than 125° C. for a duration sufficient to change calcium phosphate grains on the surface of the starting material into calcium phosphate needles
Data Source
AI summary
The invention relates to a method for producing an osteoinductive calcium phosphate material, the method comprising the steps of providing a sintered calcium phosphate starting material having a surface topography consisting of calcium phosphate grains, subjecting the sintered calcium phosphate starting material to a hydrothermal treatment of between 125-150° C. for a duration sufficient to change calcium phosphate grains on the surface of the starting material into calcium phosphate needles.