Compressed Calcium Phosphate Tablets for Controlled Spinal Placement
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Solution Overview
Problem
Calcium phosphate-based compositions are powders that are difficult to handle, require manual or machine mixing, and pose risks such as unwanted migration and nerve damage during spinal procedures.
Innovation Solution
A compressed solid object of calcium phosphate and phosphoserine or phosphocreatine, with a density of 1.20-1.80 g/cm³, is formed by applying 10-150 MPa pressure, allowing easy handling and controlled placement with minimal pressure, and mixed with an aqueous solution to form an adhesive paste.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium phosphate-based compositions are used as powders, then they provide biocompatibility and bone similarity, but they are difficult to handle and require manual or machine mixing
Solution Approach 1:
The powder mixture is pre-compressed into a solid object before application. This preliminary action transforms the difficult-to-handle powder into an easy-to-manage solid form that can be directly placed in the target area without requiring mixing equipment or manual mixing operations.
Solution Approach 2:
The physical state of the calcium phosphate composition is changed from powder (solid particles) to a compressed solid object. This parameter change in physical form maintains the biocompatible properties while dramatically improving handling characteristics and eliminating the need for mixing operations.
2Adaptability or versatility
If injectable calcium phosphate materials are used, then they can be applied to spinal areas, but they pose risks of unwanted migration and nerve damage
Solution Approach 1:
The calcium phosphate material is pre-formed into a solid object with a specific shape that matches the target spinal defect geometry. This preliminary shaping action ensures that when the material is placed in the spinal area, it maintains its form and does not migrate to unwanted locations, while still adapting to the specific anatomical requirements.
Solution Approach 2:
The solid object is designed with specific local geometric properties that match the target spinal defect. This local quality matching ensures the material stays in the correct position and does not migrate, while still providing the necessary adaptability for spinal applications.
3Ease of operation
If compressed solid objects are used, then handling is easy and placement is accurate, but the material requires compression to achieve the desired density
Solution Approach 1:
The compression process is performed as a preliminary action during manufacturing, creating the solid object before it reaches the user. This eliminates the need for the end-user to perform compression operations, maintaining ease of operation while achieving the desired density through pre-compression.
4Ease of manufacture
If manual or machine mixing is required, then the powder can be prepared, but it increases loss of time and requires additional equipment
Solution Approach 1:
The mixing and compression operations are performed as preliminary actions during manufacturing. The powder is pre-mixed and pre-compressed into the final solid object before delivery to the user, eliminating the need for time-consuming mixing operations at the point of application.
Solution Approach 2:
The mixing and compression operations are merged into a single integrated manufacturing process that produces the final solid object in one operation, eliminating separate mixing steps and reducing overall preparation time.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solid object facilitates accurate delivery, reduces migration risks, and enhances mechanical properties, providing a stable adhesive paste with improved handling and absorption properties.
Implementation Method 1
mixed with an aqueous solution to form an adhesive paste
Data Source
Figure 1a~2c
Figure 3a~3c
Figure 4~5
AI summary
A solid object having a shape wherein the solid object comprises a powder wherein the powder is a mixture of particles wherein said particles comprises a calcium phosphate compound and phosphoserine or phosphocreatine; and wherein the solid object has a density of 1.20-1.80g/cm3.