Calcium Silicate Bone Cement with Gelatin for Handling and Setting
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Calcium silicate-based bone cements face challenges with long setting times, brittleness, and difficulty in delivering and compacting due to poor handling properties, which affect their ability to maintain shape and integrate with living tissue effectively.
Innovation Solution
A method involving a sol-gel process to produce calcium silicate-based bone cement by mixing calcium and silicon precursors, followed by heating and adding gelatin to enhance plasticity, grinding, and incorporating a phosphate solution, which results in a cement with improved injectability and bioactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium silicate-based bone cement is used, then bioactivity is improved, but setting time is prolonged
Solution Approach 1:
The patent modifies the chemical composition parameters of the calcium silicate-based cement by incorporating specific amounts of polymers (0.1-10 wt%) and oligomers (0.1-10 wt%), which changes the setting reaction kinetics to achieve faster setting while preserving bioactivity
Solution Approach 2:
The patent creates a composite material system combining calcium silicate-based cement with polymers and oligomers, where the polymer-oligomer matrix accelerates setting through controlled reaction mechanisms while the calcium silicate phase maintains bioactivity
2Reliability
If calcium silicate-based bone cement is used, then bioactivity is improved, but brittleness increases
Solution Approach 1:
The patent develops a composite material where calcium silicate-based cement particles are embedded in a polymer-oligomer matrix, combining the bioactivity of inorganic calcium silicate with the toughness and flexibility of organic polymers to reduce brittleness
Solution Approach 2:
The patent creates local quality differentiation where the polymer-oligomer matrix provides flexibility and shock absorption in regions prone to stress, while calcium silicate particles maintain bioactivity at the bone-cement interface
3Reliability
If calcium silicate-based bone cement is used, then bioactivity is improved, but handling properties deteriorate
Solution Approach 1:
The patent adjusts the rheological parameters of the cement paste by incorporating polymers and oligomers in optimized quantities, modifying viscosity and flow characteristics to improve injectability and compactability while maintaining bioactivity
Solution Approach 2:
The patent introduces polymers and oligomers as intermediary substances that act as processing aids, improving the flow and handling characteristics of the cement paste during application without compromising the underlying bioactive calcium silicate chemistry
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cement exhibits faster setting times, enhanced bioactivity, and improved mechanical properties, allowing for better integration with bone tissue and easier handling, while maintaining bioactivity and bonding capabilities.
Implementation Method 1
adding gelatin to enhance plasticity
Implementation Method 2
A method involving a sol-gel process to produce calcium silicate-based bone cement by mixing calcium and silicon precursors
Implementation Method 3
heating and adding gelatin to enhance plasticity, grinding
Implementation Method 4
heating the mixture of step (b)
Implementation Method 5
incorporating a phosphate solution, which results in a cement with improved injectability and bioactivity
Data Source
Figure 1(A)~1(B)
Figure 1(C)~1(D)
Figure 2
AI summary
The present invention provides a method for producing calcium silicate-based bone cement and a composition produced by the method. It further provides a novel composition for bone tissue repair.