Calcium Silicate Powder for Oily Substance Stabilization

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Conventional oily substance-containing powders face issues with oxidation stability and compression moldability, leading to defects like lamination and reduced tablet hardness, especially when a high content of oily substances is involved.

Innovation Solution

The use of a powdery calcium silicate-based material with a specific pore structure, where the cumulative pore volume for 10-70 nm is 1.1 cc/g or more and 70-500 nm is 2.0 cc/g or less, effectively supports and stabilizes the oily substance, preventing oxidation and enhancing moldability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional oily substance-containing powders are used, then the oily substance can be delivered, but oxidation stability is insufficient and storability is impaired

Engineering Contradiction:
Improveoxidation stabilityVSAvoidstorability
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent employs a porous calcium silicate material as a carrier to adsorb and support the oily substance. The porous structure provides high surface area for adsorption while protecting the oily substance from oxidation, thereby improving both oxidation stability and storability without compromising delivery effectiveness.

Inventive Principle:
Principle #31Porous materials

Solution Approach 2:

The calcium silicate carrier acts as an intermediary between the oily substance and the environment. It adsorbs the oily substance onto its surface and within its pores, mediating the interaction between the oil and external factors like oxygen and moisture, thus preventing oxidation while maintaining stability.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Quantity of substance

If a large amount of oil components is contained in the powder, then the functional efficacy is enhanced, but the molded body exhibits low hardness and compression moldability deteriorates

Engineering Contradiction:
Improveoily substance contentVSAvoidmolded body hardness
Core Design Contradiction:
Quantity of substanceVSStrength

Solution Approach 1:

The porous calcium silicate carrier can accommodate large amounts of oily substance within its pore structure. The rigid porous framework provides structural support to the molded body, maintaining hardness even when high concentrations of oily substance are loaded, thus resolving the contradiction between quantity and strength.

Inventive Principle:
Principle #31Porous materials

Solution Approach 2:

The patent creates a composite material system combining the calcium silicate carrier with the oily substance. This composite structure leverages the mechanical strength and porous architecture of the carrier to support high oil loads while maintaining molded body integrity and hardness.

Inventive Principle:
Principle #40Composite materials

3Ease of manufacture

If compression molding is applied to oily substance-containing powder, then tablet form is achieved, but lamination occurs due to seeping of oily component

Engineering Contradiction:
Improvetablet formationVSAvoidlamination defect
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The porous calcium silicate carrier adsorbs the oily substance within its pore network, restraining it from migrating or seeping during compression molding. This prevents lamination defects while still allowing successful tablet formation, as the oily substance remains固定在 the carrier structure.

Inventive Principle:
Principle #31Porous materials

Solution Approach 2:

The calcium silicate carrier mediates the compression molding process by providing a stable adsorbed state for the oily substance. During tablet formation, the carrier protects the oil from seeping out, ensuring uniform compression and preventing lamination while maintaining ease of manufacture.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach results in improved oxidation stability and compression moldability, preventing lamination and maintaining high tablet hardness, even with high oily substance content, thereby enhancing the product's stability and usability.

Implementation Method 1

a powdery calcium silicate-based material, and an oily substance impregnated into the material

Methodology Applied
Scientific EffectAdsorption: Adsorption

Data Source

PatentUS10517825B2Powder composition containing oily substance
Publication Date: 2019.12.31 TOMITA PHARMACEUTICAL CO LTD
  • US10517825B2 patent drawing

AI summary

Provided is a powder composition containing an oily substance, the powder composition having good oxidation stability and excellent compression moldability. The powder composition containing an oily substance contains a powdery calcium silicate-based material, and an oily substance impregnated into the material. In the material, a cumulative pore volume for a pore size of 10 to 70 nm is 1.1 cc/g or more, and a cumulative pore volume for a pore size of 70 to 500 nm is 2.0 cc/g or less.