Calibration Curve for Bodily-Fluid Measurement Light Source Variation
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Solution Overview
Problem
Existing body fluid component measuring instruments face challenges in maintaining measurement accuracy due to individual variations in the spectral characteristics of light sources, requiring frequent calibration operations that increase manufacturing costs and management complexity.
Innovation Solution
A calibration method that estimates reference and individual detection values based on spectral radiation characteristics, allowing for the determination of a calibration curve that converts detection values from an individual light source to a reference light source, eliminating the need for sample measurement or exchange, and ensuring accurate measurements without spectral characteristic deviations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If calibration operations are performed using sample measurement for each instrument, then measurement accuracy is ensured, but manufacturing costs increase and management complexity increases
Solution Approach 1:
The patent creates a virtual copy of the spectral reflection characteristic through mathematical modeling. Instead of physically measuring samples for each instrument calibration, the system uses spectral radiation characteristics to calculate and estimate detection values, creating a virtual calibration model that replicates the effect of physical sample measurement without the associated complexity and cost
Solution Approach 2:
The patent transforms the calibration approach by changing from physical parameter measurement (actual sample detection) to mathematical parameter calculation (spectral characteristic-based estimation). By using spectral radiation characteristics and spectral reflection characteristics to compute detection values, the system maintains measurement accuracy while eliminating the need for repeated physical sample measurements
2Measurement precision
If calibration operations are performed using sample measurement for each instrument, then measurement accuracy is ensured, but manufacturing costs increase
Solution Approach 1:
The patent replaces expensive physical sample measurement with a virtual calibration model based on spectral characteristics. This copying approach allows the system to maintain measurement accuracy while avoiding the repeated cost of physical samples and calibration operations for each instrument
Solution Approach 2:
The system enables self-calibration through mathematical modeling. Each instrument can determine its own calibration parameters by measuring spectral radiation characteristics and calculating detection values based on spectral reflection characteristics, eliminating the need for external calibration services or expensive sample-based calibration procedures
3Measurement precision
If frequent calibration operations are performed, then measurement accuracy is maintained, but time consumption increases
Solution Approach 1:
The patent performs calibration preparation in advance by establishing the spectral reflection characteristic model and spectral radiation characteristic data. This preliminary action allows the system to quickly calculate detection values without performing repeated time-consuming physical calibration operations, maintaining measurement accuracy while reducing calibration time
Solution Approach 2:
The virtual calibration model created through spectral characteristic analysis serves as a time-efficient copy of the actual calibration process. Once the spectral reflection characteristic model is established, the system can rapidly calculate detection values for multiple instruments without repeating the full calibration procedure, significantly reducing calibration time while maintaining accuracy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach ensures accurate measurement of body fluid components by converting detection values from individual light sources to a standard reference, maintaining measurement precision without the need for frequent calibration operations or sample exchange, thereby simplifying the calibration process and reducing costs.
Implementation Method 1
a detection value related to reflected light obtained by projecting light on a test strip
Implementation Method 2
a test strip impregnated with a reagent that develops color corresponding to the amount of glucose in the blood
Data Source
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AI summary
The present invention relates to a method, apparatus, and program for calibration, and a body fluid component measuring instrument calibrated by using the same method. A reference detection value for each of samples (26s) when a reference light source (50s) is used is each estimated, and also an individual detection value when an individual light source (50r) that is the same type as the reference light source (50s) and that is to be mounted on a calibration target instrument (10c) is each estimated. Based on a relationship in each combination between the reference detection value and the individual detection value, each estimated for each of the samples (26s), a calibration curve is determined. With the calibration curve, the detection value on a test strip (26) on the calibration target instrument (10c) having the individual light source (50r) mounted thereon is converted into the detection value when the reference light source (50s) is used.