Calibration Offset Compensation in Agent Delivery Devices
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Solution Overview
Problem
Delivery devices that rely on sensor values for agent delivery often face issues due to sensor calibration loss, leading to incorrect dosages and potential health complications like hypoglycemia or hyperglycemia.
Innovation Solution
A method involving a processor that receives calibrated analyte measurements, updates past sensor measurements to correct for calibration offsets, and adjusts dosages and delivery constraints to compensate for past delivery discrepancies, using techniques like fingerstick blood glucose meters for accurate calibration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If sensor values are used for ongoing agent delivery decisions, then the delivery device can operate continuously with automated dosing, but the sensor calibration may drift over time causing offset errors in measurements
Solution Approach 1:
The system performs preliminary calibration actions by receiving calibrated analyte measurements from alternative sources (fingerstick blood glucose meters) and uses these to determine calibration offsets before the sensor drifts too far from accuracy. The calibrated measurements are stored and used to correct future uncalibrated measurements, preventing accumulation of dosing errors.
Solution Approach 2:
The system implements feedback by comparing uncalibrated sensor measurements against previously received calibrated measurements, calculating the difference as a calibration offset. This offset is then applied to correct subsequent measurements, creating a continuous feedback loop that maintains measurement accuracy despite sensor drift over time.
2Ease of operation
If uncalibrated sensor measurements are used to determine dosages, then the delivery device can operate without frequent user intervention, but incorrect dosages may be delivered leading to hypoglycemia or hyperglycemia
Solution Approach 1:
The system introduces an intermediary calibration offset calculation that mediates between uncalibrated sensor measurements and accurate dosing decisions. The offset, derived from calibrated reference measurements, acts as a correction factor that translates inaccurate sensor data into reliable dosing information without requiring frequent manual calibration by the user.
Solution Approach 2:
The system dynamically changes the measurement parameter by applying a calibration offset to transform uncalibrated sensor readings into corrected analyte measurements. This parameter adjustment allows the system to maintain dosage accuracy despite changes in sensor calibration status over time.
3Measurement precision
If calibrated measurements from alternative sources are obtained frequently, then measurement accuracy can be maintained, but user burden and device complexity increase
Solution Approach 1:
The system applies partial calibration action by using calibrated measurements from alternative sources only when needed to determine calibration offsets, rather than requiring continuous calibration. The offset calculation is performed selectively based on when calibrated measurements are received, reducing the overall calibration burden while maintaining sufficient accuracy.
Data Source
AI summary
Exemplary embodiments may compensate for loss of calibration by sensors that provide sensed analyte measurements to delivery devices. The exemplary embodiments may obtain one or more calibrated analyte measurements, such as by using techniques to obtain that the analyte measurement value that are known to produce properly calibrated analyte values. The one or more calibrated analyte measurements are compared to a recent analyte measurement to determine a negative or positive offset. The offset may be added to the recent analyte measurement to generate an updated analyte measurement that reflects the calibrated analyte measurement. In addition, past analyte measurement values within a time window may be updated as well by adding the offset to the past analyte measurement values. The exemplary embodiments may also compensate for the past over-delivery or under-delivery of an agent by the delivery device due to the loss of calibration.