Callus Lysate Extraction via Mechanical Homogenization

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Conventional methods for extracting beneficial components from callus for human skin application face challenges such as inefficiency, high organic solvent usage, and energy-intensive processes, leading to incomplete utilization of plant nutrients and economic inefficiencies.

Innovation Solution

Mechanical homogenization of callus at specific pressures to break down cell walls, allowing for enhanced extraction and absorption of metabolites without significant loss, followed by encapsulation for improved stability and skin penetration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional extraction methods using organic solvents are used to extract beneficial components from callus, then specific components can be extracted, but the extraction efficiency is low and large amounts of organic solvents are consumed

Engineering Contradiction:
Improveextraction efficiency of beneficial componentsVSAvoidconsumption of organic solvents
Core Design Contradiction:
Quantity of substanceVSLoss of substance

Solution Approach 1:

The patent extracts beneficial components from callus using water-based extraction followed by concentration and drying processes, eliminating the need for organic solvents while maintaining extraction efficiency of metabolites such as antioxidants and moisturizing components

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the extraction parameter from organic solvent to water, and uses concentration and drying parameters to achieve high-content extract without requiring large volumes of solvent, thus resolving the contradiction between extraction efficiency and solvent consumption

Inventive Principle:
Principle #35Parameter changes

2Loss of substance

If supercritical extraction is used to avoid organic solvents, then no organic solvents are used, but expensive equipment and high energy consumption are required

Engineering Contradiction:
Improveusage of organic solventsVSAvoidenergy consumption and equipment cost
Core Design Contradiction:
Loss of substanceVSUse of energy by moving object

Solution Approach 1:

The patent uses simple, inexpensive equipment for water extraction, concentration, and drying instead of expensive supercritical extraction equipment, achieving solvent-free extraction with low energy consumption and accessible technology

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent replaces the complex mechanical and thermal system of supercritical extraction with a simpler system combining water extraction, concentration, and drying processes, reducing both equipment cost and energy requirements while avoiding organic solvents

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Quantity of substance

If conventional extraction methods highly integrate only some beneficial components, then specific components are concentrated, but other beneficial components are lost or wasted

Engineering Contradiction:
Improveconcentration of specific beneficial componentsVSAvoidloss of other beneficial components
Core Design Contradiction:
Quantity of substanceVSLoss of substance

Solution Approach 1:

The patent uses a universal water-based extraction method that simultaneously extracts multiple types of beneficial components including antioxidants, moisturizing components, and other metabolites, rather than targeting single components, thus preserving the full spectrum of callus benefits

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Quantity of substance

If callus itself is applied to human skin, then metabolites are present in the callus, but the metabolites cannot be taken in through human skin due to the indegradable cell wall

Engineering Contradiction:
Improvecontent of callus metabolitesVSAvoidpenetration and absorption of metabolites into skin
Core Design Contradiction:
Quantity of substanceVSEase of operation

Solution Approach 1:

The patent extracts metabolites from the callus cell structure using water-based extraction, releasing the metabolites from their encapsulated state in the cell wall, thereby making them available for skin penetration and absorption while preserving all metabolite content

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method achieves higher content and better absorption of callus metabolites, improving skin moisturization, wrinkle prevention, skin whitening, and elasticity, with enhanced skin permeability and stability of the active ingredients.

Implementation Method 1

mechanical homogenization of the callus at a specific pressure

Methodology Applied
Scientific EffectMechanical Force: Mechanical Force

Data Source

PatentUS11975095B2Callus lysate comprising high content of callus metabolite and preparation method thereof
Publication Date: 2024.05.07 BIOSPECTRUM

AI summary

Disclosed is a callus lysate containing a callus metabolite without a loss of callus metabolite and its preparation method, a capsule containing a callus lysate prepared through encapsulation by coating the callus lysate with a natural polymer material and its preparation method, and composition for external skin application and a cosmetic composition that includes the callus lysate or the capsule containing the callus lysate as an active ingredient, wherein the callus lysate of the present invention contains a large amount of a callus metabolite without a loss of callus metabolite and thus allows penetration or absorption of callus metabolite directly into the skin, thereby providing effects of the callus metabolite to prevent and improve various skin diseases and symptoms.