Camellia Sinensis Root Extract for Selective Senolytic Skin Therapy

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Solution Overview

Problem

Current senolytic substances are highly cytotoxic and primarily used as anticancer drugs, making them unsuitable for cosmetic use and ineffective against skin cells.

Innovation Solution

A senolytic and senomorphic composition utilizing tea tree root extract as an active ingredient, which selectively removes senescent cells and inhibits the production of Senescence Associated Secretory Phenotype (SASP), thereby improving skin elasticity and reducing aging-related diseases.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If highly cytotoxic senolytic substances are used to selectively remove senescent cells, then senolytic efficacy is improved, but safety and suitability for cosmetic use deteriorate

Engineering Contradiction:

Improvesenolytic efficacyVSAvoidcytotoxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses natural polyphenols from Camellia sinensis root extract as temporary, biodegradable agents that induce senescent cell death through apoptosis without requiring persistent toxic substances. These natural compounds degrade after performing their function, avoiding long-term cytotoxicity concerns

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the chemical parameters by using natural polyphenolic compounds with specific molecular structures (catechins, flavonoids) that have selective toxicity toward senescent cells. The composition optimizes concentration ranges (0.01-10% w/w) to achieve effective senolytic activity while maintaining safety margins for cosmetic application

Inventive Principle:

Principle #35Parameter changes

2Productivity

If existing senolytic substances are used, then senescent cell removal is effective, but effectiveness against skin cells deteriorates

Engineering Contradiction:

Improvesenescent cell removal efficiencyVSAvoideffectiveness against skin cells

Core Design Contradiction:

ProductivityVSAdaptability or versatility

Solution Approach 1:

The patent applies local quality by formulating the composition specifically for topical skin application. The polyphenol composition targets skin-specific senescent cells (fibroblasts, keratinocytes) with localized action, considering the unique physiological environment of skin tissue and barrier requirements

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent uses a composite of multiple polyphenolic compounds from Camellia sinensis root extract, including catechins, flavonoids, and other phenolic substances. This composite approach provides synergistic effects that enhance senolytic activity against skin cells while maintaining stability and safety for cosmetic use

Inventive Principle:

Principle #40Composite materials

Data Source

PatentEP4494631A1A senotherapy composition containing camellia sinensis extract

Publication Date: 2025.01.22 AMOREPACIFIC CORP

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AI summary

Disclosed herein is a method for senotherapy; prevention, improvement or treatment of aging-related disease; improvement of skin elasticity or wrinkles; improvement of skin barrier; or improvement of skin pigmentation, containing administering an effective amount of tea tree (Camellia Sinensis) root extract to a subject in need thereof. In one aspect, a senotherapy composition containing the tea tree (Camellia Sinensis) root extract has an excellent senolytic effect to selectively remove senescent cells and an excellent senomorphic effect to inhibit the production of senescence associated secretory phenotype (SASP) of senescent cells.