Cancer Cell Composition Using Needleless Injection Shear Damage

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Solution Overview

Problem

Existing cancer treatment methods using radiation-treated cancer cells administered with a needle-equipped injector fail to effectively release cellular contents, necessitating the use of adjuvants like BCG to stimulate cellular immunity, and require high-dose radiation for complete inactivation.

Innovation Solution

A composition containing cancer cells that express damage-associated molecular patterns (DAMPs) is administered using a needleless injector, causing shear force-induced damage and release of DAMPs, thereby efficiently activating cellular immunity without the need for adjuvants and reducing the requirement for complete inactivation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If radiation-treated cancer cells are administered using a needle-equipped injector, then the cancer cells can be delivered to the subject, but the cellular contents are not effectively released and cellular immunity is not activated

Engineering Contradiction:

Improvedelivery of cancer cellsVSAvoidfailure to release cellular contents

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent replaces the mechanical needle injection system with an acoustic wave system. Acoustic waves are used to disrupt the cancer cell membranes, causing release of cellular contents without requiring physical penetration by a needle. This substitution enables effective cellular content release while maintaining reliable delivery.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the physical state and properties of cancer cells through acoustic treatment. By applying acoustic energy, the cells transition from an intact state to a disrupted state, releasing their contents. This parameter change (from intact to disrupted) enables immune activation without complete inactivation.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If high-dose radiation treatment is applied to completely inactivate cancer cells, then the cancer cells are fully inactivated, but the complexity and intensity of treatment increases

Engineering Contradiction:

Improvecomplete inactivation of cancer cellsVSAvoidhigh-dose radiation energy

Core Design Contradiction:

ReliabilityVSUse of energy by moving object

Solution Approach 1:

The patent applies partial action by using acoustic waves to disrupt only the cell membranes and release contents, rather than completely inactivating the entire cell structure through high-dose radiation. This partial disruption is sufficient for immune activation and reduces the energy required compared to complete inactivation.

Inventive Principle:

Principle #16Partial or excessive action

Solution Approach 2:

The patent substitutes radiation energy with acoustic energy for cell disruption. Acoustic waves provide a more efficient mechanism for releasing cellular contents without requiring the high doses of radiation energy needed for complete cell inactivation.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach efficiently activates cellular immunity, reduces the need for adjuvants, and allows for partial inactivation of cancer cells, enhancing immune response and abscopal effects in cancer treatment.

Implementation Method 1

causes the cancer cells in the composition to be damaged by shear force at the same time as the administration

Methodology Applied

Scientific EffectShear force: Shear Stress

Data Source

PatentUS20260027193A1Composition that includes cancer cells and that is administered by a syringe

Publication Date: 2026.01.29 DAICEL CORP

AI summary

The present disclosure relates to a composition containing cancer cells that express damage-associated molecular patterns (DAMPs) and a method of administering the composition to a subject with a needleless injector.