Candida infanticola Microbial Dioic Acid Production

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Solution Overview

Problem

The production of dioic acids from petrochemical raw materials is environmentally detrimental, economically volatile due to price fluctuations, and relies on scarce natural resources, necessitating a sustainable and renewable alternative.

Innovation Solution

A method utilizing the Candida infanticola strain to produce dioic acids from substrates containing hydrocarbons or fatty acids, involving culturing the strain in yeast extract glucose medium, inducing ω-oxidation reactions with specific carbon sources, and optimizing growth conditions for efficient dioic acid production.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If petrochemical raw materials are used to produce dioic acids, then production efficiency is high, but environmental pollution increases and resource scarcity worsens

Engineering Contradiction:

Improveproduction efficiencyVSAvoidenvironmental pollution

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The invention changes the fundamental parameter of raw material source from petrochemical to renewable plant-based feedstocks. This parameter change enables sustainable production while maintaining industrial scalability, resolving the contradiction between high productivity and environmental protection by transitioning to a different material basis rather than optimizing the existing petrochemical process

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention replaces the chemical petrochemical processing system with a biological fermentation system using microorganisms. This substitution allows the production process to occur under milder conditions with renewable resources, achieving both high productivity through efficient microbial conversion and reduced environmental impact through biodegradable processes

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If petrochemical raw materials are used to produce dioic acids, then production cost is stable, but resource scarcity increases

Engineering Contradiction:

Improveproduction stabilityVSAvoidresource availability

Core Design Contradiction:

ProductivityVSQuantity of substance

Solution Approach 1:

The invention uses plant-based feedstocks that can serve multiple functions and sources (various agricultural crops, waste biomass, sustainable plant oils). This universality ensures continuous availability of raw materials regardless of petroleum market fluctuations, maintaining production stability while accessing renewable resources that are not subject to the same scarcity constraints

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The invention changes the resource base from finite petroleum reserves to renewable plant biomass. This parameter change transforms the availability profile from depleting to regenerative, ensuring long-term resource sustainability while maintaining stable production through established agricultural supply chains and fermentation processes

Inventive Principle:

Principle #35Parameter changes

3Manufacturing precision

If complex multi-step synthesis is used to produce dioic acids, then manufacturing precision is high, but process complexity increases

Engineering Contradiction:

Improveproduct purityVSAvoidprocess complexity

Core Design Contradiction:

Manufacturing precisionVSDevice complexity

Solution Approach 1:

The invention replaces complex multi-step chemical synthesis with a single-step biological fermentation process. Microorganisms naturally perform the chemical transformations needed to convert plant feedstocks into dioic acids with high specificity, achieving product purity without requiring multiple processing stages, intermediate purification steps, or complex reaction control systems

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The invention utilizes the microorganism's inherent metabolic pathways to perform the synthesis automatically. The biological system self-regulates the conversion process, maintaining optimal conditions for producing high-purity dioic acids through natural enzymatic reactions, eliminating the need for complex external control mechanisms and multiple processing stages

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method reduces environmental impact and economic volatility by providing a renewable source for dioic acids, enhancing production efficiency and yield while utilizing a microbial approach that is less dependent on fossil fuels.

Implementation Method 1

adding a carbon source or a substrate containing hydrocarbons, fatty acids or its derivatives to induce ω-oxidation reaction

Methodology Applied

Scientific Effectω-oxidation: Oxidation

Data Source

PatentUS10837032B2<i>Candida infanticola </i>strain, mutant strain and transformant strain thereof, and method for producing dioic acids using same

Publication Date: 2020.11.17 LOTTE CHEM CORP

AI summary

The present invention relates to a method for producing dioic acids from a substrate containing hydrocarbons or fatty acids using a Candida infanticola strain, and to a Candida infanticola microorganism used therefor. The present invention reduces the cost increase resulting from the fluctuation in the international oil price and the burden of environmental pollution, which are caused by the use of fossil fuels, and thus can be utilized in various industrial fields using DDDA as a raw material.