Cannabidiol Topical Composition for Equine Insect Bite Hypersensitivity
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Solution Overview
Problem
Current treatments for equine insect bite hypersensitivity (IBH) are inadequate, leading to chronic and seasonal itching in horses, with existing methods often causing side effects and not addressing the underlying cause of the disorder.
Innovation Solution
The use of cannabidiol (CBD) topically applied to skin lesions to reduce pruritus and inflammation, formulated in concentrations between 0.001 μg/mL to 1000 mg/mL with a veterinary acceptable carrier, providing a pharmaceutical preparation for prevention and treatment of IBH.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If corticosteroids are used to reduce itching effects, then pruritus symptoms are alleviated, but unwanted side effects occur and the underlying cause is not treated
Solution Approach 1:
The patent introduces CBD as an intermediary substance that mediates between the inflammatory response and symptom expression. CBD acts on cannabinoid receptors in the endocannabinoid system to modulate immune response and reduce inflammation, providing an alternative pathway that does not involve the harmful side effects of corticosteroids while still achieving symptom relief
Solution Approach 2:
The patent changes the pharmacological parameter from corticosteroid-based anti-inflammatory mechanisms to cannabinoid-based modulation. This involves shifting from suppressing immune function broadly to selectively modulating the endocannabinoid system, thereby achieving anti-pruritic effects through a different biochemical pathway that avoids steroid-related side effects
2Object-affected harmful factors
If conventional treatments are applied to IBH symptoms, then some symptom relief is achieved, but the underlying cause of the disorder remains untreated
Solution Approach 1:
The patent applies CBD topically to the skin lesions before significant systemic inflammation develops, aiming to prevent the progression of the allergic response. By intervening early at the site of insect bites and initial inflammation, CBD can potentially prevent the full development of the hypersensitivity reaction rather than merely treating established symptoms
3Object-affected harmful factors
If topical treatments are applied to skin lesions, then local symptom relief is achieved, but systemic absorption and adverse effects may occur
Solution Approach 1:
The patent employs topical application of CBD directly to the affected skin lesions, creating a localized high concentration of the active compound at the site of inflammation. This local delivery method ensures that the therapeutic effect is concentrated where needed while minimizing systemic distribution and potential adverse effects from widespread exposure
Data Source
AI summary
The present invention is directed to use of cannabidiol and compositions thereof as preventive and curative agent for IBH. The invention is further directed to related methods and compositions.