Cannabinoid Carboxylic Acid Salt Purification
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Solution Overview
Problem
Current methods for producing pure neutral cannabinoids are laborious, prone to impurity formation, and lack efficiency, particularly in the purification of cannabinoid carboxylic acids which are ideal precursors for obtaining pure cannabinoids.
Innovation Solution
A method involving the production of crystalline and soluble salts of cannabinoid carboxylic acids through chemical reaction or extraction from Cannabis sativa, followed by mixing with suitable organic or inorganic bases in solvents to precipitate sparingly soluble salts, which can be purified by recrystallization and decomposed to yield pure neutral cannabinoids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If complex purification processes such as preparative chromatography are used to produce pure neutral cannabinoids, then manufacturing precision is improved, but device complexity and loss of time increase
Solution Approach 1:
The invention extracts and utilizes cannabinoid carboxylic acids as intermediate compounds from the decarboxylation process, separating them from the complex mixture before final purification. This extraction step simplifies the overall purification process by removing impurities early in the sequence, reducing the need for complex chromatographic steps while maintaining high purity of the final neutral cannabinoid product
Solution Approach 2:
The invention performs preliminary decarboxylation to convert cannabinoid carboxylic acids into neutral cannabinoids, and further preliminary purification steps to remove impurities before the final isolation. By performing these actions in advance, the subsequent purification requires less complex equipment and procedures, resolving the contradiction between purity and process complexity
2Manufacturing precision
If multiple purification steps including chromatography and vacuum distillation are employed, then manufacturing precision is improved, but loss of time increases
Solution Approach 1:
The invention merges multiple purification operations into a integrated process flow where decarboxylation, filtration, and concentration steps are combined sequentially. By merging these operations that can be performed in a single reaction vessel or connected system, the invention reduces the total time required while maintaining the purity benefits of multiple purification steps
Solution Approach 2:
The invention skips certain intermediate isolation steps by performing sequential reactions and purifications without isolating each intermediate product. The process rushes through multiple purification stages by maintaining continuous flow or sequential batch operations, significantly reducing the time loss associated with repeated isolation and re-dissolution cycles while still achieving high purity through the combined effect of multiple purification mechanisms
3Manufacturing precision
If crystallizable precursors are produced through complex processes including recrystallization and saponification, then manufacturing precision is improved, but device complexity and susceptibility to impurity formation increase
Solution Approach 1:
The invention converts the potentially harmful effect of impurity formation during complex purification processes into a benefit by using selective crystallization of cannabinoid carboxylic acid salts. The process exploits the differential solubility and crystallization behavior of various compounds to separate impurities from the desired product, transforming what would be a source of contamination into a purification mechanism that simplifies the overall process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method allows for the economical and efficient production of pure, crystalline salts of cannabinoid carboxylic acids, reducing the effort required and susceptibility to impurities, enabling the simple and effective conversion to pure neutral cannabinoids.
Implementation Method 1
reacting them with a suitable organic base, inorganic base and/or a suitable inorganic or organic salt in a suitable solvent
Implementation Method 2
followed by mixing with suitable organic or inorganic bases in solvents to precipitate sparingly soluble salts
Implementation Method 3
which can be purified by recrystallization
Implementation Method 4
decomposed to yield pure neutral cannabinoids
Implementation Method 5
the so-called 'neutral cannabinoids' are formed by decarboxylation, i.e., the removal of CO2
Data Source
AI summary
The invention relates to a compound selected from the group consisting of all stereoisomers and their mixtures of the compounds of general formulas (1)-(4), in which R1 is a straight-chained, branched or cyclic hydrocarbon group with up to 12 C-atoms and X+ is selected from the group consisting of H+, NH4 +, mono, di or trivalent metal cations, NH4 +, primary, secondary, tertiary or quaternary organic ammonium ions with up to 48 C-atoms, which can carry even more functional groups, hydrazinium ion (N2H5 +), hydroxylammonium ion (NH3OH+), guanidinium ion (CN3H6 +), and organic derivatives of (N2H5 +), NH3OH+, and CN3H6 +, which can carry even more functional groups, and similar. A method is also provided for producing these compounds, comprising the following steps: producing synthetic cannabinoid carboxylic acids in a chemical reaction, or extracting natural cannabinoid carboxylic acids from plant material or cell cultures of Cannabis sativa, and adding a suitable inorganic base, a suitable organic base and/or a suitable inorganic or organic salt in a suitable solvent, to the cannabinoid carboxylic acids or cannabinoid carboxylic acid-rich extracts produced in this manner.