Aerosolizable Cannabinoid Material Stability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing aerosol delivery systems face challenges in formulating aerosolizable materials that ensure stability, user acceptability, and consistent quality, particularly when incorporating cannabinoids like cannabidiol, due to issues such as water solubility and the need for surface active constituents.
Innovation Solution
An aerosolizable material comprising (+)-cannabidiol combined with carrier constituents like propylene glycol and glycerol, which maintains stability and user acceptability without requiring surface active agents, ensuring a turbidity of 10 Nephelometric Turbidity Units (NTU) or less and optimal solubility in a propylene glycol/glycerol system.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If water is used as a carrier constituent, then solubility of cannabinoids is improved, but stability of the aerosolizable material deteriorates due to precipitation
Solution Approach 1:
The patent changes the chemical parameters of the carrier system by selecting specific organic carriers (propylene glycol, glycerol, medium chain triglycerides) with controlled viscosity, boiling point, and solubility characteristics. This parameter optimization allows achieving both adequate cannabinoid solubility and long-term stability without precipitation, resolving the contradiction between solubility improvement and stability maintenance.
Solution Approach 2:
The patent employs composite carrier formulations combining multiple constituents (e.g., propylene glycol mixed with glycerol or medium chain triglycerides) in specific ratios. This composite approach leverages the complementary properties of each carrier to achieve both high cannabinoid solubility and enhanced formulation stability, preventing the precipitation issue that arises with water alone.
2Ease of manufacture
If surface active constituents are added to improve aerosolization, then ease of manufacture is improved, but user acceptability deteriorates
Solution Approach 1:
The patent extracts and eliminates surface active constituents from the formulation, relying instead on the inherent aerosolization properties of the selected carrier constituents (propylene glycol, glycerol, medium chain triglycerides). These carriers naturally facilitate aerosol generation without requiring additional surfactants, thereby maintaining ease of manufacture while preserving user acceptability by avoiding potentially unpleasant surface active agents.
Solution Approach 2:
The patent uses the carrier constituents themselves as intermediaries that perform the dual function of solubilizing cannabinoids and facilitating aerosolization. The carriers act as mediating substances that enable efficient aerosol generation through their physical properties (viscosity, surface tension, volatility) without requiring separate surface active additives, thus resolving the contradiction between manufacturability and user acceptance.
3Ease of operation
If turbidity is reduced to improve quality perception, then user acceptability is improved, but manufacturing precision requirements increase
Solution Approach 1:
The patent optimizes formulation parameters (carrier composition ratios, cannabinoid concentration, purity levels) to inherently achieve low turbidity formulations. By carefully selecting and proportioning carriers with appropriate solubility and refractive index properties, the formulation naturally produces clear aerosolizable material with minimal turbidity, meeting quality perception requirements while maintaining feasible manufacturing precision standards.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation provides a stable and user-acceptable aerosolizable material that prevents cannabinoid precipitation and ensures efficient transfer of constituents to the aerosol, maintaining system performance and user perception of quality.
Implementation Method 1
an aerosolizable material which is heated to form a vapor which is then allowed to condense into an aerosol
Implementation Method 2
a vapor which is then allowed to condense into an aerosol
Implementation Method 3
the aerosol generated is an aerosol which results from the atomization of the aerosolizable material. Such atomization may be brought about mechanically, e.g. by subjecting the aerosolizable material to vibrations so as to form small particles of material that are entrained in airflow
Data Source
AI summary
An aerosolizable material is provided. The aerosolizable material comprises (+)-cannabidiol and at least one carrier constituent. Methods of making the aerosolizable material and articles comprising the aerosolizable material are also provided.