Cannabinoid Anion Solubility via Brønsted Base Deprotonation

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Solution Overview

Problem

Cannabinoids are insoluble in water, leading to unfavorable characteristics in cannabinoid beverages such as undesirable flavor and poor bioavailability, which disrupts the cannabinoid beverage industry.

Innovation Solution

The development of cannabinoid anions that dissolve in water, converting into neutral or acidic pH-compatible molecules, improving bioavailability and compatibility with ingredients, using containers with barriers to inhibit fluid communication until consumption, and employing Brønsted bases and acids to deprotonate and reconvert the anionic molecules for solubility and flavor change.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If cannabinoids are suspended in water using emulsification, then cannabinoid beverages can be produced, but the beverages display undesirable flavor and poor bioavailability

Engineering Contradiction:

Improveability to produce cannabinoid beveragesVSAvoidundesirable flavor and poor bioavailability

Core Design Contradiction:

Ease of manufactureVSObject-generated harmful factors

Solution Approach 1:

The patent changes the chemical state of cannabinoids from neutral molecules to anionic forms through deprotonation using Brønsted bases. This parameter change transforms cannabinoids from water-insoluble to water-soluble, eliminating the need for emulsification and directly resolving the flavor and bioavailability problems while maintaining ease of manufacture

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces Brønsted bases as intermediary substances that facilitate the conversion of cannabinoids to their anionic, water-soluble forms. These bases act as mediators between the hydrophobic cannabinoids and hydrophilic water, enabling direct dissolution without emulsifiers and thereby improving flavor and bioavailability

Inventive Principle:

Principle #24Intermediary (Mediator)

2Adaptability or versatility

If cannabinoid anions are converted into neutral molecules at neutral or acidic pH, then compatibility with ingredients is improved, but solubility in water decreases

Engineering Contradiction:

Improvecompatibility with ingredientsVSAvoidsolubility in water

Core Design Contradiction:

Adaptability or versatilityVSQuantity of substance

Solution Approach 1:

The patent applies preliminary action by converting cannabinoids to their anionic, water-soluble forms before mixing with incompatible ingredients. The container system maintains this soluble state during storage and mixing, then allows conversion to neutral forms at the moment of consumption, ensuring both solubility during preparation and compatibility at consumption

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent implements dynamics by creating a pH-responsive system where cannabinoid anions dynamically convert to neutral molecules based on environmental pH conditions. This dynamic equilibrium allows the system to adapt: maintaining solubility in alkaline conditions during storage and mixing, then converting to compatible neutral forms at neutral/acidic pH during consumption

Inventive Principle:

Principle #15Dynamics

3Quantity of substance

If cannabinoid anions are protected from neutral or acidic pH, then solubility and compatibility are maintained, but mixing with incompatible ingredients is limited

Engineering Contradiction:

Improvesolubility and compatibilityVSAvoidability to mix with incompatible ingredients

Core Design Contradiction:

Quantity of substanceVSAdaptability or versatility

Solution Approach 1:

The patent applies segmentation by dividing the beverage system into distinct compartments: one containing cannabinoid anions in alkaline pH and another containing incompatible ingredients. This physical segmentation allows both components to coexist without premature reaction, enabling mixing capability while maintaining solubility and compatibility until consumption

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the bioavailability and flavor of cannabinoid beverages by maintaining solubility and compatibility with ingredients for minutes to hours, improving the overall consumption experience.

Implementation Method 1

Cannabinoid anions convert into cannabinoid molecules at neutral or acidic pH

Methodology Applied

Scientific EffectProtonation:

Implementation Method 2

employing Brønsted bases and acids to deprotonate and reconvert the anionic molecules

Methodology Applied

Scientific EffectDeprotonation:

Implementation Method 3

containers with barriers to inhibit fluid communication until consumption

Methodology Applied

Scientific EffectPhysical containment: Physical Containment

Data Source

PatentUS20220233404A1Containers, compositions, and methods related to cannabinoid anions

Publication Date: 2022.07.28 NATURAL EXTRACTION SYSTEMS LLC

AI summary

Various aspects of this patent document relate cannabinoid anions including methods to produce cannabinoid anions, compositions comprising cannabinoid anions, containers that contain compositions comprising cannabinoid anions, and methods to consume cannabinoid anions.