Cannabinoid Medical Chewing Gum Base Polymers
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Solution Overview
Problem
Current methods for administering cannabinoids for pain relief, such as inhalation, smoking, and medical tablets, face challenges like rapid absorption, low bioavailability, swallowing difficulties, high costs, and unpleasant taste, particularly in medical chewing gum formulations where the release profile and texture are complex to manage.
Innovation Solution
A medical chewing gum comprising gum base polymers with polyvinyl acetate and vinyl laurate-vinyl acetate copolymer, offering a better release profile and improved taste masking, with a compressed form that facilitates faster and more efficient cannabinoid release, reducing the need for excessive taste masking ingredients and minimizing unpleasant taste perception.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional chewing gum bases are used to deliver cannabinoids, then the chewing gum can be formulated, but the release profile is poor and excessive taste masking ingredients are required
Solution Approach 1:
The patent changes the chemical composition parameters of the gum base by specifying exact proportions of polyvinyl acetate (40-70%), vinyl laurate-vinyl acetate copolymer (20-50%), and polyisobutylene (10-30%). This parameter optimization enables effective cannabinoid release with minimal taste masking, resolving the contradiction between release efficiency and taste acceptability.
Solution Approach 2:
The patent creates a composite gum base material combining three specific polymers in optimized ratios. This composite formulation synergistically provides both effective cannabinoid delivery and inherent taste masking properties, eliminating the need for excessive additional taste masking ingredients.
2Object-generated harmful factors
If more taste masking ingredients are added to mask cannabinoid bitterness, then the taste improves, but the release profile of cannabinoid deteriorates
Solution Approach 1:
The patent optimizes the gum base composition parameters to inherently mask bitter tastes while maintaining cannabinoid release. By adjusting the polymer ratios and selecting specific materials with appropriate release characteristics, the formulation achieves taste masking without compromising release profile.
3Ease of operation
If the chewing gum is made softer to ease chewing, then the chewing texture improves, but the cannabinoid release increases excessively
Solution Approach 1:
The patent precisely controls the softness parameter of the gum base by optimizing the molecular weights and proportions of the three polymers. This parameter optimization achieves the desired balance between chewing ease and controlled cannabinoid release, preventing excessive release while maintaining patient comfort.
4Shape
If the chewing gum is made harder to maintain typical textural properties, then the chewing gum texture is preserved, but the cannabinoid release is reduced
Solution Approach 1:
The patent employs a composite polymer system where each component contributes specific textural and release properties. The synergistic combination maintains authentic chewing gum texture while enabling effective cannabinoid release, resolving the contradiction between texture preservation and release efficiency.
Data Source
AI summary
A medical chewing gum including gum base polymers and one or more cannabinoids as an active pharmaceutical ingredient, the gum base polymers including polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight of the gum base polymers, wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer.