Cannabinoid Detection Device Using Neural Circuit Conductivity
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Solution Overview
Problem
Current technologies lack the capability to efficiently and cost-effectively test for cannabinoid intoxication in real-time using portable systems, particularly below 25 ng/ml for Delta-9 Tetrahydrocannabinoid in saliva and sub 5 ng/ml in blood, due to the absence of clear regulations for synthetic cannabinoids and the complexity of measuring Cannabinoid-Mediated Depolarization Induced Suppression of Inhibition (C-DISI).
Innovation Solution
A portable cannabinoid detection device (CDD) that sends electrical voltage pulses across neural circuits on a chip, measuring conductivity changes caused by cannabinoid binding to CB1 receptors, allowing for real-time toxicity analysis in blood and saliva, with calibration using THC standards and linear regression, and capable of detecting multiple cannabinoid molecules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If portable testing systems are used for cannabinoid detection, then ease of operation and accessibility are improved, but measurement precision and detection sensitivity are worsened
Solution Approach 1:
The patent replaces complex mechanical laboratory equipment with an electrical field-based detection system. The C-DISI assay uses electrical voltage pulses to stimulate neural circuits on a chip, measuring conductivity changes to detect cannabinoid presence. This substitution of mechanical/chemical laboratory methods with electrical measurement enables portable device implementation while maintaining high detection sensitivity.
Solution Approach 2:
The patent changes the detection parameter from measuring physical presence or chemical composition to measuring electrical conductivity changes. By monitoring the electrical properties of neural circuits when cannabinoid molecules bind to CB1 receptors and cause depolarization-induced suppression of inhibition, the system achieves high sensitivity detection in a portable format.
2Measurement precision
If sophisticated laboratory equipment is used for cannabinoid testing, then measurement precision is improved, but device complexity and cost are worsened
Solution Approach 1:
The patent segments the detection system into a simple portable device with a removable chip containing the neural circuit. The chip can be easily replaced, and the main device remains simple and portable. This segmentation allows complex neural circuit functionality to be contained in a small, replaceable component while the overall system remains simple and accessible.
Solution Approach 2:
The patent uses a chip with cultured neural circuits as an intermediary between the portable device and the complex biological detection process. The neural circuits on the chip serve as a mediator that translates cannabinoid presence into measurable electrical conductivity changes, simplifying the detection process while maintaining accuracy.
3Speed
If real-time detection is implemented, then speed of detection is improved, but measurement precision and reliability are worsened
Solution Approach 1:
The patent enables continuous real-time monitoring of electrical conductivity in the neural circuit. Rather than performing discrete, intermittent tests, the system continuously measures the electrical properties of the neural circuit, providing ongoing detection of cannabinoid presence and maintaining both speed and precision through uninterrupted measurement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate, real-time field testing for cannabinoid intoxication with extreme accuracy, reducing the need for sophisticated equipment and expertise, while allowing for reuse and cost-effective recycling of the testing chip, thus making cannabinoid impairment detection practical and accessible.
Implementation Method 1
Cannabinoid intoxication in humans has been determined to be a function of a mechanism known as Cannabinoid-Mediated Depolarization Induced Suppression of Inhibition (C-DISI). C-DISI is an electrically measureable process of decoupling a neural circuit in the human brain. C-DISI occurs when a psycho active cannabinoid molecule binds to a neural Glycolipid-Protein receptor in the human brain known as the Cannabinoid Receptor type 1 (CB1). The C-DISI outcome of the cannabinoid binding results in a voltage drop from a positively stimulated voltage to −30 to 0 mV.
Data Source
AI summary
A method for quantifying the intoxicating affect of natural and synthetic Cannabinoids on Humans. The method includes the capacity to measure a human's psychoactive intoxication as a function of Cannabinoid-Mediated Depolarization-Induced Suppression of Inhibition (C-DISI) relative to the Cannabinoid Receptors found in the Human brain. A Method incorporating the ability to also quantify the affects of Cannabinoids on the various Cannabinoid Receptors found in the Human body. Neurons are used as transistors in a solid state electronic configuration with an apparatus to measure the toxicity of a given aqueous solution comprised of one or more Cannabinoid analytes. Said method incorporates a novel recycling process affiliated with analyte acquisition & testing.