Cannabinoid Oil-in-Water Emulsion for Parenteral Stability

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Solution Overview

Problem

Current cannabinoid-based pharmaceutical preparations for parenteral administration face challenges in achieving long-term stability and high bioavailability while minimizing side effects.

Innovation Solution

The development of an oil-in-water emulsion for parenteral administration, where cannabinoids are incorporated into the oil phase in very small droplets, enhancing stability and absorption, and reducing side effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If cannabinoids are administered via conventional parenteral preparations, then administration route is achieved, but stability and bioavailability are insufficient

Engineering Contradiction:

ImprovestabilityVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent transforms the physical state of cannabinoid administration from conventional solutions or suspensions to an oil-in-water emulsion system with specifically controlled droplet size parameters (mean diameter 50-500 nm). This parameter change in droplet size distribution fundamentally improves stability and bioavailability while reducing side effects through optimized particle characteristics

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite emulsion system combining oil phase (containing cannabinoids and lipophilic components) with aqueous phase, stabilized by surfactants. This composite structure allows simultaneous achievement of cannabinoid solubility, emulsion stability, and controlled bioavailability that neither phase could achieve alone

Inventive Principle:

Principle #40Composite materials

2Productivity

If droplet size is reduced to increase bioavailability, then absorption improves, but manufacturing precision requirements increase

Engineering Contradiction:

ImprovebioavailabilityVSAvoiddroplet size control

Core Design Contradiction:

ProductivityVSManufacturing precision

Solution Approach 1:

The patent employs preliminary emulsification steps followed by controlled homogenization to pre-establish the droplet size distribution before final formulation. This preliminary action ensures that the emulsion reaches the target droplet size range (50-500 nm) systematically, making the manufacturing process more controllable and reproducible

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The oil-in-water emulsion provides improved stability and bioavailability of cannabinoids, leading to reduced side effects and enhanced therapeutic effectiveness.

Implementation Method 1

The development of an oil-in-water emulsion for parenteral administration, where cannabinoids are incorporated into the oil phase in very small droplets

Methodology Applied

Scientific EffectEmulsion: Emulsion

Data Source

PatentEP4541347A1Liquid pharmaceutical formulation for intravenous, subcutaneous, or intramuscular administration of one or more cannabinoids

Publication Date: 2025.04.23 SATIVARI UG (HAFTUNGSBESCHRÄNKT)

AI summary

The present invention relates to an emulsion consisting of at least one oil phase and at least one aqueous phase, characterized in that the emulsion contains at least one cannabinoid in the at least one oil phase. Furthermore, the emulsion is used for medicinal purposes.