Cannabinoid Aerosol Formulation pH Control and Stabilization
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Solution Overview
Problem
Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) in aerosol formulations are prone to degradation due to exposure to air, light, and variations in temperature and pH, leading to the formation of unwanted derivatives and potential loss of potency, which can result in inconsistent product quality and regulatory issues.
Innovation Solution
Incorporating stabilizing components like antioxidants, radical scavengers, and pH modulators into the formulation, while maintaining a pH of less than 7.5, to mitigate oxidation and degradation of cannabinoids, ensuring high purity and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are formulated in aerosol delivery systems, then they can be delivered to users, but they are prone to degradation due to exposure to air, light, and temperature variations
Solution Approach 1:
The patent applies inert atmosphere by formulating the cannabinoid composition with pH modulators and stabilizing agents that create a chemically inert environment within the aerosol system. The pH modulator maintains a specific pH range that prevents degradation, effectively creating a protective chemical environment that isolates cannabinoids from harmful oxidative and hydrolytic reactions that would otherwise occur upon exposure to air and moisture.
Solution Approach 2:
The patent uses pH modulators and stabilizing agents as intermediary substances that mediate between the cannabinoids and the harmful environmental factors. These intermediaries absorb or neutralize the effects of air, light, and temperature variations, protecting the cannabinoids from direct degradation while allowing the aerosol delivery system to function.
2Reliability
If stabilizing components are added to prevent degradation, then cannabinoid stability improves, but formulation complexity increases
Solution Approach 1:
The patent applies universality by selecting pH modulators that perform multiple functions simultaneously: they maintain the required pH range to prevent degradation, act as stabilizing agents against oxidation and hydrolysis, and ensure compatibility with aerosol delivery systems. This multi-functionality reduces the need for separate additives for each protective function, thereby limiting the increase in formulation complexity.
Solution Approach 2:
The patent uses parameter changes by optimizing the pH range and concentrations of stabilizing components to achieve maximum protection with minimal formulation complexity. By identifying and controlling critical parameters such as pH and stabilizer concentration, the patent achieves reliable cannabinoid stability without requiring complex multi-component formulations.
3Reliability
If pH is controlled to maintain stability, then cannabinoid degradation is reduced, but manufacturing precision requirements increase
Solution Approach 1:
The patent applies preliminary action by incorporating pH modulators and stabilizing agents during the formulation manufacturing process itself, rather than attempting to adjust pH after formulation. This preliminary establishment of the correct pH range and stabilizing environment simplifies manufacturing by built-in protection mechanisms, reducing the need for precise post-manufacturing pH adjustments and quality control interventions.
Solution Approach 2:
The patent uses self-service by designing a formulation system where pH modulators automatically maintain the pH within the optimal range through buffer action and equilibrium chemistry. The formulation self-regulates its pH and stability characteristics without requiring continuous external monitoring or adjustment, thereby reducing manufacturing precision requirements while maintaining cannabinoid stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of stabilizing components effectively reduces the formation of unwanted derivatives, maintains cannabinoid potency, and ensures consistent product quality, preventing unintended conversion of CBD to THC and maintaining stability during storage and use.
Implementation Method 1
mitigate oxidation and degradation of cannabinoids
Implementation Method 2
maintaining a pH of less than 7.5, to mitigate oxidation and degradation of cannabinoids
Implementation Method 3
Incorporating stabilizing components like antioxidants, radical scavengers, and pH modulators
Data Source
AI summary
A formulation, a method of making said formulation, as well as containers and systems including and using said formulation. In particular, the formulation includes one or more cannabinoids, one or more stabilizing component and one or more carrier constituents, wherein the total amount of the one or more carrier constituents is 50% w/w or more based on the total weight of the formulation, wherein said formulation has a pH of less than about 7.5.