Cannabinoid Therapy Formulations for Sleep and Pain

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Solution Overview

Problem

There is a need for more effective and safer cannabis products for various medical uses, particularly in addressing sleep, pain, and anxiety conditions, as existing products often have limitations in efficacy and safety.

Innovation Solution

The development of cannabinoid therapy formulations comprising negative allosteric modulators of the cannabinoid receptor 1 (CB1), partial agonists, CB1 antagonists or negative allosteric modulators, gamma-aminobutyric acid (GABA)A receptor activators, and transient receptor potential cation channel, subfamily A, member 1 (TRPA1) activators, in specific ratios and combinations, along with other botanicals, to target the endocannabinoid system for improved therapeutic outcomes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If single cannabinoid products are used, then simplicity of product formulation is maintained, but therapeutic efficacy is limited

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidproduct formulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines multiple cannabinoids (CBD, CBN, CBG) in specific ratios within a single product formulation to achieve synergistic therapeutic effects. This merging of multiple active ingredients resolves the contradiction by improving efficacy through combination while maintaining product simplicity through integrated formulation.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates composite cannabinoid formulations with specific ratios of different cannabinoids (e.g., CBD:CBN:CBG = 2:1:1 or 3:1:1). These composite materials provide enhanced therapeutic efficacy compared to single cannabinoids, resolving the contradiction between simplicity and effectiveness.

Inventive Principle:

Principle #40Composite materials

2Reliability

If higher doses of cannabinoids are administered, then therapeutic outcomes are improved, but adverse events increase

Engineering Contradiction:

Improvetherapeutic outcomesVSAvoidadverse events

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the dosage parameters of individual cannabinoids within the combination. By adjusting the ratios and doses of CBD, CBN, and CBG to specific ranges, the formulation achieves therapeutic outcomes at lower total doses compared to single cannabinoid products, thereby reducing adverse events while maintaining efficacy.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention uses lower doses of multiple cannabinoids to achieve the same or better therapeutic effects compared to high doses of single cannabinoids. This converts the potential harm of high dosing into the benefit of reduced side effects while maintaining or improving therapeutic outcomes through synergistic combination.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Reliability

If existing cannabis products are used, then availability is maintained, but safety is compromised

Engineering Contradiction:

ImprovesafetyVSAvoidproduct effectiveness for specific conditions

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates specialized cannabinoid formulations tailored to specific therapeutic conditions (sleep, pain, anxiety) with optimized ratios of CBD, CBN, and CBG. This local quality approach improves safety and effectiveness for specific conditions rather than using generic cannabis products for all purposes.

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS20240050451A1Precision cannabinoid therapy formulations and methods of use

Publication Date: 2024.02.15 MDM ENTERPRISE SOLUTIONS INC

AI summary

Described herein are cannabinoid therapy formulations for sleep, pain, and anxiety conditions. Also provided are methods for improving sleep quality, relieving pain and/or improving anxiety symptoms.