Cannabinoid-Glucosamine Complexes for Aqueous Solubility

The patent applies composite materials by combining cannabinoids with hydrophilic carriers such as cyclodextrins, phospholipids, or proteins to form complex structures. This composite approach allows the lipophilic cannabinoid core to retain its biological activity while the hydrophilic outer layer provides water solubility, thus resolving the contradiction between maintaining original chemical structure and improving water solubility.

The patent uses hydrophilic carriers as intermediary substances that mediate between the lipophilic cannabinoid and the aqueous environment. These intermediaries (cyclodextrins, phospholipids, proteins) form inclusion complexes or micellar structures that shield the hydrophobic cannabinoid from water while exposing hydrophilic surfaces, thereby enabling water solubility without compromising the cannabinoid's biological activity.

The patent applies beforehand cushioning by incorporating antioxidants and stabilizing agents into the formulation before the decarboxylation process can occur. These protective substances are added in advance to prevent or slow down the spontaneous decarboxylation of acidic cannabinoids in aqueous solutions, thereby maintaining their biological activity while still achieving improved bioavailability through enhanced water solubility.

The patent creates an inert environment by using controlled packaging and storage conditions that minimize exposure to heat, light, and oxygen - the three main factors that accelerate decarboxylation. By formulating the aqueous solution with appropriate pH buffers and storing it under controlled conditions, the patent creates a protective environment that slows down spontaneous decarboxylation while maintaining the acidic cannabinoid's bioavailability.