Cannabinoid Chewing Gum Composition for Controlled Mucosal Release
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Solution Overview
Problem
Existing chewing gum formulations for delivering cannabinoids face challenges with compromised sensorics characteristics, such as texture and flavor perception, due to high amounts of water-soluble ingredients, and struggle with controlled release and off-notes, which affect convenience and efficacy.
Innovation Solution
A chewing gum composition comprising 10-40% natural resin, 3-30% elastomers, 8-50% elastomer plasticizers, and 35-80% sugar alcohols, with cannabinoids either unbound or homogeneously distributed in sugar alcohols, to improve texture, flavor perception, and achieve controlled release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If water-soluble chewing gum ingredients (sugar alcohols) are present in relatively high amounts to improve sweetness and texture, then sensorics characteristics are enhanced, but controlled release of cannabinoids is compromised
Solution Approach 1:
The invention divides the chewing gum into distinct functional layers: a water-soluble outer layer containing sugar alcohols and flavoring agents that provides immediate sensorics benefits, and a water-insoluble inner gum base layer containing cannabinoids that ensures controlled release. This segmentation allows each layer to perform its specific function without interfering with the other.
Solution Approach 2:
The invention uses a specific gum base composition containing natural resins, elastomers, and plasticizers as an intermediary matrix that mediates between the water-soluble sweetening ingredients and the cannabinoid delivery system. This intermediary gum base structure allows high sugar alcohol content for sensorics while maintaining the integrity and controlled release of cannabinoids.
2Stability of the object's composition
If conventional gum bases are used to provide structural integrity, then chewing gum stability is maintained, but release properties and sensorics properties of cannabinoids are compromised
Solution Approach 1:
The invention changes the compositional parameters of the gum base by specifying precise ranges for natural resins (10-40%), elastomers (3-30%), and elastomer plasticizers (8-50%). This parameter optimization transforms the gum base from a conventional structural material into an active delivery system that enhances both stability and cannabinoid release properties.
Solution Approach 2:
The invention creates a composite gum base material combining natural resins, elastomers, and plasticizers in specific proportions. This composite structure provides the mechanical stability needed for chewing gum while simultaneously improving the release properties and sensorics characteristics of cannabinoids, overcoming the limitations of conventional single-material gum bases.
3Quantity of substance
If higher amounts of cannabinoids are delivered to improve therapeutic effect, then medical efficacy is enhanced, but off-notes and adverse side effects increase
Solution Approach 1:
The optimized gum base composition acts as an intermediary delivery matrix that controls the release kinetics of cannabinoids. By using natural resins, elastomers, and plasticizers in specific ratios, the system mediates between high cannabinoid loading for therapeutic effect and controlled release that prevents overwhelming the sensory system, thereby reducing off-notes and adverse effects.
Solution Approach 2:
The invention achieves periodic or sustained release of cannabinoids through the specific gum base composition, rather than immediate release. This controlled periodic delivery allows therapeutic amounts of cannabinoids to be released gradually over time, preventing the sudden high concentrations that cause off-notes and adverse side effects while maintaining effective therapeutic levels.
Data Source
AI summary
The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum including water-soluble chewing gum ingredients and water-insoluble gum base, wherein the gum base has one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the water-soluble chewing gum ingredients include one or more sugar alcohols in an amount of 35-80% by weight of the chewing gum, and wherein the chewing gum has one or more cannabinoids.