Cannabinoid Chewing Gum with Polyvinyl Acetate Plasticizers
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Solution Overview
Problem
Existing chewing gum formulations for cannabinoid delivery suffer from rapid blood absorption issues, adverse side effects, and inadequate sensory properties, leading to inefficient and uncomfortable administration.
Innovation Solution
A novel chewing gum formulation featuring a water-soluble gum base with 10-40% natural resins, 3-30% elastomers, and 8-50% elastomer plasticizers, including polyvinyl acetate, which enhances the release profile and sensory characteristics of cannabinoids, providing a controlled and sustained release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional gum bases are used for cannabinoid delivery, then prolonged release is achieved, but sensory properties (initial chew, texture, flavor perception) deteriorate
Solution Approach 1:
The patent employs a composite gum base formulation combining natural resins (10-40% w/w), elastomers (3-30% w/w), and elastomer plasticizers (8-50% w/w). This composite material approach allows the formulation to achieve both prolonged cannabinoid release and improved sensory properties including initial chew, texture, and flavor perception, resolving the contradiction between release duration and sensory quality.
2Duration of action of moving object
If conventional gum bases are used for cannabinoid delivery, then prolonged release is achieved, but cannabinoid release efficiency deteriorates
Solution Approach 1:
The patent modifies the chemical and physical parameters of the gum base by incorporating specific ratios of natural resins (10-40% w/w), elastomers (3-30% w/w), and elastomer plasticizers (8-50% w/w). These parameter changes optimize both the duration and efficiency of cannabinoid release, allowing for improved release kinetics while maintaining prolonged delivery.
3Speed
If cannabinoids are administered by inhalation or smoking, then rapid blood absorption is achieved, but safety and side effects worsen
Solution Approach 1:
The patent uses chewing gum as an intermediary delivery system that avoids the harmful effects of inhalation and smoking. The gum base formulation with natural resins, elastomers, and plasticizers provides controlled cannabinoid release through mucosal delivery, achieving safe and effective administration without the respiratory hazards associated with traditional methods.
4Quantity of substance
If conventional gum bases are used, then cannabinoid delivery is achieved, but off-notes and adverse side effects worsen
Solution Approach 1:
The patent optimizes the formulation parameters by incorporating elastomer plasticizers (8-50% w/w) that specifically reduce off-notes and adverse effects. This parameter modification in the gum base composition allows for effective cannabinoid delivery while minimizing harmful sensory effects and side effects.
Data Source
AI summary
The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum including water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base has one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the one or more elastomer plasticizers includes one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum has one or more cannabinoids.